A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus

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Farmakis , D , Agostoni , P , Baholli , L , Bautin , A , Comin-Colet , J , Crespo-Leiro , M G , Fedele , F , García-Pinilla , J M , Giannakoulas , G , Grigioni , F , Gruchała , M , Gustafsson , F , Harjola , V-P , Hasin , T , Herpain , A , Iliodromitis , E K , Karason , K , Kivikko , M , Liaudet , L , Ljubas-Maček , J , Marini , M , Masip , J , Mebazaa , A , Nikolaou , M , Ostadal , P , Põder , P , Pollesello , P , Polyzogopoulou , E , Pölzl , G , Tschope , C , Varpula , M , von Lewinski , D , Vrtovec , B , Yilmaz , M B , Zima , E & Parissis , J 2019 , ' A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus ' , International Journal of Cardiology , vol. 297 , pp. 83-90 . https://doi.org/10.1016/j.ijcard.2019.09.005

Title: A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus
Author: Farmakis, Dimitrios; Agostoni, Piergiuseppe; Baholli, Loant; Bautin, Andrei; Comin-Colet, Josep; Crespo-Leiro, Maria G.; Fedele, Francesco; García-Pinilla, Jose Manuel; Giannakoulas, George; Grigioni, Francesco; Gruchała, Marcin; Gustafsson, Finn; Harjola, Veli-Pekka; Hasin, Tal; Herpain, Antoine; Iliodromitis, Efstathios K.; Karason, Kristjan; Kivikko, Matti; Liaudet, Lucas; Ljubas-Maček, Jana; Marini, Marco; Masip, Josep; Mebazaa, Alexandre; Nikolaou, Maria; Ostadal, Petr; Põder, Pentti; Pollesello, Piero; Polyzogopoulou, Eftihia; Pölzl, Gerhard; Tschope, Carsten; Varpula, Marjut; von Lewinski, Dirk; Vrtovec, Bojan; Yilmaz, Mehmet Birhan; Zima, Endre; Parissis, John
Other contributor: University of Helsinki, HUS Emergency Medicine and Services
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, HUS Heart and Lung Center






Date: 2019-12-15
Language: eng
Number of pages: 8
Belongs to series: International Journal of Cardiology
ISSN: 0167-5273
DOI: https://doi.org/10.1016/j.ijcard.2019.09.005
URI: http://hdl.handle.net/10138/309256
Abstract: Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators. Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure, (i) the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine, (ii) the phosphodiesterase III inhibitor milrinone and (iii) the calcium sensitizer levosimendan. These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure. (C) 2019 The Authors. Published by Elsevier B.V.
Subject: 3121 General medicine, internal medicine and other clinical medicine
Acute heart failure
Advanced heart failure
Inotropes
Inodilators
Levosimendan
Dobutamine
Milrinone
Norepinephrine
LONG-TERM
MORTALITY
INTERMITTENT LEVOSIMENDAN TREATMENT
MILRINONE
CLINICAL CHARACTERISTICS
SYSTOLIC FUNCTION
REPETITIVE USE
CARDIOGENIC-SHOCK
INFUSIONS
QUALITY-OF-LIFE
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