Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

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http://hdl.handle.net/10138/309285

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ADHD Working Grp Psychiat Genomics , Early Lifecourse Genetic , 23andMe Res Team & Daly , M J 2019 , ' Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder ' , Nature Genetics , vol. 51 , no. 1 , pp. 63-+ . https://doi.org/10.1038/s41588-018-0269-7

Title: Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Author: ADHD Working Grp Psychiat Genomics; Early Lifecourse Genetic; 23andMe Res Team; Daly, Mark J.
Other contributor: University of Helsinki, Institute for Molecular Medicine Finland

Date: 2019-01
Language: eng
Number of pages: 16
Belongs to series: Nature Genetics
ISSN: 1061-4036
DOI: https://doi.org/10.1038/s41588-018-0269-7
URI: http://hdl.handle.net/10138/309285
Abstract: Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.
Subject: DEFICIT HYPERACTIVITY DISORDER
LD SCORE REGRESSION
ASSOCIATION METAANALYSIS
GENETIC ARCHITECTURE
PROVIDES INSIGHTS
MAJOR DEPRESSION
SEXUAL-BEHAVIOR
POLYGENIC RISK
IDENTIFIES 11
US CHILDREN
1184 Genetics, developmental biology, physiology
3111 Biomedicine
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