Feline Infectious Peritonitis as a Systemic Inflammatory Disease : Contribution of Liver and Heart to the Pathogenesis

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Malbon , A J , Fonfara , S , Meli , M L , Hahn , S , Egberink , H & Kipar , A 2019 , ' Feline Infectious Peritonitis as a Systemic Inflammatory Disease : Contribution of Liver and Heart to the Pathogenesis ' , Viruses-Basel , vol. 11 , no. 12 , 1144 . https://doi.org/10.3390/v11121144

Title: Feline Infectious Peritonitis as a Systemic Inflammatory Disease : Contribution of Liver and Heart to the Pathogenesis
Author: Malbon, Alexandra J.; Fonfara, Sonja; Meli, Marina L.; Hahn, Shelley; Egberink, Herman; Kipar, Anja
Contributor: University of Helsinki, Veterinary Biosciences
University of Helsinki, Veterinary Biosciences
University of Helsinki, Veterinary Biosciences
Date: 2019-12
Language: eng
Number of pages: 17
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/311170
Abstract: Feline infectious peritonitis (FIP) is a fatal immune-mediated disease of cats, induced by feline coronavirus (FCoV). A combination of as yet poorly understood host and viral factors combine to cause a minority of FCoV-infected cats to develop FIP. Clinicopathological features include fever, vasculitis, and serositis, with or without effusions; all of which indicate a pro-inflammatory state with cytokine release. As a result, primary immune organs, as well as circulating leukocytes, have thus far been of most interest in previous studies to determine the likely sources of these cytokines. Results have suggested that these tissues alone may not be sufficient to induce the observed inflammation. The current study therefore focussed on the liver and heart, organs with a demonstrated ability to produce cytokines and therefore with huge potential to exacerbate inflammatory processes. The IL-12:IL-10 ratio, a marker of the immune system's inflammatory balance, was skewed towards the pro-inflammatory IL-12 in the liver of cats with FIP. Both organs were found to upregulate mRNA expression of the inflammatory triad of cytokines IL-1 beta, IL-6, and TNF-alpha in FIP. This amplifying step may be one of the missing links in the pathogenesis of this enigmatic disease.
Subject: feline infectious peritonitis
feline coronavirus
hepatocytes
cardiomyocytes
inflammatory cytokines
pathogenesis
systemic inflammatory response
GROWTH-FACTOR VEGF
MESSENGER-RNA
TNF-ALPHA
CORONAVIRUS INFECTION
VASCULAR-PERMEABILITY
ADHESION MOLECULES
CYTOKINE RESPONSES
INTERFERON-GAMMA
IMMUNE-RESPONSE
REGULATES VEGF
1183 Plant biology, microbiology, virology
413 Veterinary science
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