Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

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Lallukka , S , Luukkonen , P K , Zhou , Y , Isokuortti , E , Leivonen , M , Juuti , A , Hakkarainen , A , Orho-Melander , M , Lundbom , N , Olkkonen , V M , Lassila , R & Yki-Järvinen , H 2017 , ' Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans ' , Thrombosis and Haemostasis , vol. 117 , no. 2 , pp. 286-294 . https://doi.org/10.1160/TH16-09-0716

Title: Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans
Author: Lallukka, Susanna; Luukkonen, Panu K.; Zhou, You; Isokuortti, Elina; Leivonen , Marja; Juuti, Anne; Hakkarainen, Antti; Orho-Melander, Marju; Lundbom, Nina; Olkkonen, Vesa M.; Lassila, Riitta; Yki-Järvinen, Hannele
Contributor organization: HUS Internal Medicine and Rehabilitation
Department of Medicine
Clinicum
II kirurgian klinikka
Department of Surgery
HUS Abdominal Center
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Department of Oncology
Hematologian yksikkö
HUSLAB
HUS Comprehensive Cancer Center
Date: 2017-02
Language: eng
Number of pages: 9
Belongs to series: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: https://doi.org/10.1160/TH16-09-0716
URI: http://hdl.handle.net/10138/311599
Abstract: Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of several coagulation factors, VWF:RCo and fibrinogen, and D-dimer concentration in 92 subjects divided into groups based on insulin sensitivity [insulin-resistant ('IR') versus insulin-sensitive ('IS')] and PNPLA3 genotype (PNPLA3(148MM/MI) vs PNPLA3(148II)). Liver fat content (H-1-MRS) was similarly increased in 'IR' (13 +/- 1%) and PNPLA3(148MM/MI) (12 +/- 2%) as compared to 'IS' (6 +/- 1%, p
Subject: Adipose tissue
inflammation
fibrinogen
insulin
non-alcoholic fatty liver disease
CARDIOVASCULAR RISK-FACTORS
C-REACTIVE PROTEIN
INSULIN-RESISTANCE
FACTOR-VIII
ADIPOSE-TISSUE
HEPATIC STEATOSIS
FACTOR-XIII
METABOLIC SYNDROME
VENOUS THROMBOSIS
GENETIC-VARIATION
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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