Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

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Lallukka , S , Luukkonen , P K , Zhou , Y , Isokuortti , E , Leivonen , M , Juuti , A , Hakkarainen , A , Orho-Melander , M , Lundbom , N , Olkkonen , V M , Lassila , R & Yki-Järvinen , H 2017 , ' Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans ' , Thrombosis and Haemostasis , vol. 117 , no. 2 , pp. 286-294 . https://doi.org/10.1160/TH16-09-0716

Title: Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans
Author: Lallukka, Susanna; Luukkonen, Panu K.; Zhou, You; Isokuortti, Elina; Leivonen, Marja; Juuti, Anne; Hakkarainen, Antti; Orho-Melander, Marju; Lundbom, Nina; Olkkonen, Vesa M.; Lassila, Riitta; Yki-Järvinen, Hannele
Contributor: University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, II kirurgian klinikka
University of Helsinki, II kirurgian klinikka
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
Date: 2017-02
Language: eng
Number of pages: 9
Belongs to series: Thrombosis and Haemostasis
ISSN: 0340-6245
URI: http://hdl.handle.net/10138/311599
Abstract: Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of several coagulation factors, VWF:RCo and fibrinogen, and D-dimer concentration in 92 subjects divided into groups based on insulin sensitivity [insulin-resistant ('IR') versus insulin-sensitive ('IS')] and PNPLA3 genotype (PNPLA3(148MM/MI) vs PNPLA3(148II)). Liver fat content (H-1-MRS) was similarly increased in 'IR' (13 +/- 1%) and PNPLA3(148MM/MI) (12 +/- 2%) as compared to 'IS' (6 +/- 1%, p
Subject: Adipose tissue
inflammation
fibrinogen
insulin
non-alcoholic fatty liver disease
CARDIOVASCULAR RISK-FACTORS
C-REACTIVE PROTEIN
INSULIN-RESISTANCE
FACTOR-VIII
ADIPOSE-TISSUE
HEPATIC STEATOSIS
FACTOR-XIII
METABOLIC SYNDROME
VENOUS THROMBOSIS
GENETIC-VARIATION
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
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