Add-on mirtazapine improves orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics

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http://hdl.handle.net/10138/311836

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Terevnikov , V , Stenberg , J-H , Tiihonen , J , Burkin , M & Joffe , G 2017 , ' Add-on mirtazapine improves orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics ' , Nordic Journal of Psychiatry , vol. 71 , no. 1 , pp. 77-80 . https://doi.org/10.1080/08039488.2016.1233996

Title: Add-on mirtazapine improves orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics
Author: Terevnikov, Viacheslav; Stenberg, Jan-Henry; Tiihonen, Jari; Burkin, Mark; Joffe, Grigori
Contributor organization: University of Helsinki
Clinicum
Department of Psychiatry
HUS Psychiatry
Date: 2017-01
Language: eng
Number of pages: 4
Belongs to series: Nordic Journal of Psychiatry
ISSN: 0803-9488
DOI: https://doi.org/10.1080/08039488.2016.1233996
URI: http://hdl.handle.net/10138/311836
Abstract: Aim: Sexual dysfunction, common in schizophrenia, may be further exaggerated by antipsychotics, especially those of First Generation (FGAs), and antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRs). Mirtazapine, an antidepressant characterized by its different action mechanism compared with that of the majority of other antidepressants, may improve SSRI-induced sexual dysfunction in patients with depression. It is unknown, however, whether mirtazapine improves sexual functioning in schizophrenia.Methods: This study randomly assigned FGA-treated patients with schizophrenia to receive either an add-on mirtazapine (n=20) or a placebo (n=19) for 6 weeks. Sexual functioning was prospectively measured using five relevant items from the Udvalg for Kliniske Undersogelser side-effect rating scale (UKU-SERS).Results: Orgasmic function improved with statistical significance in the mirtazapine group (p=.03), with no changes in any other sexual functions in either group.Conclusion: Add-on mirtazapine appears to relieve orgasmic dysfunction in FGA-treated patients with schizophrenia.
Subject: Mirtazapine
orgasmic dysfunction
sexual dysfunction
RCT
FGA
schizophrenia
INDUCED SEXUAL DYSFUNCTION
PLACEBO-CONTROLLED TRIAL
SEROTONIN REUPTAKE INHIBITORS
DEPRESSED-PATIENTS
DOUBLE-BLIND
ERECTILE DYSFUNCTION
ADJUNCTIVE TREATMENT
HALOPERIDOL
RISPERIDONE
OLANZAPINE
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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