Altered Bile Transporter Expression and Cholesterol Metabolism in Children With Cholesterol and Pigment Gallstones

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http://hdl.handle.net/10138/312992

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Koivusalo , A , Mutanen , A , Nissinen , M , Gylling , H & Pakarinen , M 2019 , ' Altered Bile Transporter Expression and Cholesterol Metabolism in Children With Cholesterol and Pigment Gallstones ' , Journal of Pediatric Gastroenterology and Nutrition , vol. 69 , no. 2 , pp. 138-144 . https://doi.org/10.1097/MPG.0000000000002353

Title: Altered Bile Transporter Expression and Cholesterol Metabolism in Children With Cholesterol and Pigment Gallstones
Author: Koivusalo, Antti; Mutanen, Annika; Nissinen, Markku; Gylling, Helena; Pakarinen, Mikko
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Staff Services
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Children and Adolescents
Date: 2019-08
Language: eng
Number of pages: 7
Belongs to series: Journal of Pediatric Gastroenterology and Nutrition
ISSN: 0277-2116
URI: http://hdl.handle.net/10138/312992
Abstract: Objectives: We elucidated pathophysiology of pediatric gallstone disease by assessing liver expression of bile transporters in relation to bile acids and surrogates of cholesterol absorption and synthesis in serum and gallstones. Methods: RNA expression of canalicular bile transporters in liver biopsies from 32 pediatric gallstone patients and from 6 liver donors (controls) was measured by qRT-PCR (quantitative real-time reverse transcription polymerase chain reaction). Concentrations of cholesterol and precursors, plant sterols and bile acids in gallstones, and in serum of the patients and 82 healthy children were measured. Primary outcomes were the difference in RNA expressions and serum sterol profiles between patients and controls. Results: Cholesterol stones (CS; n = 15) contained cholesterol >42% and pigment stones (PS; n = 17)
Subject: 3121 General medicine, internal medicine and other clinical medicine
PLANT STEROLS
BILE ACIDS
RNA EXPRESSION
3123 Gynaecology and paediatrics
bile acids
plant sterols
RNA expression
SURROGATE MARKERS
GALLBLADDER-DISEASE
ABSORPTION
RISK
STEROLS
LIVER
IDENTIFICATION
METAANALYSIS
ABCG5
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