A speculative outlook on embryonic aneuploidy : Can molecular pathways be involved?

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dc.contributor.author Tguiko, Olga
dc.contributor.author Jatsenko, Tatjana
dc.contributor.author Grace, Lalit Kumar Parameswaran
dc.contributor.author Kurg, Ants
dc.contributor.author Vermeesch, Joris Robert
dc.contributor.author Lanner, Fredrik
dc.contributor.author Altmae, Signe
dc.contributor.author Salumets, Andres
dc.date.accessioned 2020-03-07T23:46:46Z
dc.date.available 2021-12-17T22:45:12Z
dc.date.issued 2019-03-01
dc.identifier.citation Tguiko , O , Jatsenko , T , Grace , L K P , Kurg , A , Vermeesch , J R , Lanner , F , Altmae , S & Salumets , A 2019 , ' A speculative outlook on embryonic aneuploidy : Can molecular pathways be involved? ' , Developmental Biology , vol. 447 , no. 1 , pp. 3-13 . https://doi.org/10.1016/j.ydbio.2018.01.014
dc.identifier.other PURE: 123043344
dc.identifier.other PURE UUID: 6bf51de2-e993-4f1e-bd2b-78e37b69b828
dc.identifier.other WOS: 000459082200002
dc.identifier.other Scopus: 85041582914
dc.identifier.uri http://hdl.handle.net/10138/313086
dc.description.abstract The journey of embryonic development starts at oocyte fertilization, which triggers a complex cascade of events and cellular pathways that guide early embryogenesis. Recent technological advances have greatly expanded our knowledge of cleavage-stage embryo development, which is characterized by an increased rate of whole-chromosome losses and gains, mixoploidy, and atypical cleavage morphokinetics. Embryonic aneuploidy significantly contributes to implantation failure, spontaneous miscarriage, stillbirth or congenital birth defects in both natural and assisted human reproduction. Essentially, early embryo development is strongly determined by maternal factors. Owing to considerable limitations associated with human oocyte and embryo research, the use of animal models is inevitable. However, cellular and molecular mechanisms driving the error-prone early stages of development are still poorly described. In this review, we describe known events that lead to aneuploidy in mammalian oocytes and preimplantation embryos. As the processes of oocyte and embryo development are rigorously regulated by multiple signal-transduction pathways, we explore the putative role of signaling pathways in genomic integrity maintenance. Based on the existing evidence from human and animal data, we investigate whether critical early developmental pathways, like Wnt, Hippo and MAPK, together with distinct DNA damage response and DNA repair pathways can be associated with embryo genomic instability, a question that has, so far, remained largely unexplored. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Developmental Biology
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Aneuploidy
dc.subject Chromosomal instability
dc.subject Molecular signaling
dc.subject Preimplantation embryo
dc.subject PREIMPLANTATION HUMAN EMBRYOS
dc.subject SPINDLE ASSEMBLY CHECKPOINT
dc.subject GLYCOGEN-SYNTHASE KINASE-3
dc.subject WNT SIGNALING PATHWAYS
dc.subject DNA-DAMAGE
dc.subject CHROMOSOME SEGREGATION
dc.subject CELL-CYCLE
dc.subject MAP KINASE
dc.subject GENE-EXPRESSION
dc.subject PROTEIN STABILIZATION
dc.subject 3111 Biomedicine
dc.subject 1184 Genetics, developmental biology, physiology
dc.title A speculative outlook on embryonic aneuploidy : Can molecular pathways be involved? en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization HUS Gynecology and Obstetrics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ydbio.2018.01.014
dc.relation.issn 0012-1606
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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