A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels

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http://hdl.handle.net/10138/313162

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Nahm , D , Weigl , F , Schaefer , N , Sancho , A , Frank , A , Groll , J , Villmann , C , Schmidt , H-W , Dalton , P D & Luxenhofer , R 2020 , ' A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels ' , Materials Horizons , vol. 7 , no. 3 , pp. 928-933 . https://doi.org/10.1039/C9MH01654F

Title: A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels
Author: Nahm, Daniel; Weigl, Franziska; Schaefer, Natascha; Sancho, Ana; Frank, Andreas; Groll, Jürgen; Villmann, Carmen; Schmidt, Hans-Werner; Dalton, Paul D.; Luxenhofer, Robert
Contributor: University of Helsinki, Department of Chemistry
Date: 2020-03-01
Language: eng
Number of pages: 6
Belongs to series: Materials Horizons
ISSN: 2051-6347
URI: http://hdl.handle.net/10138/313162
Abstract: In this study, we designed a novel biomaterial ink platform based on hydrophilic poly(2-ethyl-2-oxazine) (PEtOzi) specifically for melt electrowriting (MEW). This material crosslinks spontaneously after processing via dynamic Diels–Alder click chemistry. These direct-written microperiodic structures rapidly swell in water to yield thermoreversible hydrogels. These hydrogels are robust enough for repeated aspiration and ejection through a cannula without structural damage, despite their high water content of 84%. Moreover, the scaffolds retain functional groups for modification using click chemistry and therefore can be readily functionalized as demonstrated using fluorophores and peptides to facilitate visualization and cell attachment. The PEtOzi hydrogel developed here is compatible with confocal imaging and staining protocols for cells. In summary, an advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels.
Subject: CLICK CHEMISTRY
DELIVERY
DESIGN
DIELS-ALDER REACTION
FURAN
GELATION
MALEIMIDE
POLYMER
SCAFFOLDS
TECHNOLOGY
116 Chemical sciences
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