Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD

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Hyvärinen , K , Koskela , S , Niittyvuopio , R , Nihtinen , A , Volin , L , Salmenniemi , U , Putkonen , M , Buño , I , Gallardo , D , Itälä-Remes , M , Partanen , J & Ritari , J 2020 , ' Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD ' , Frontiers in Immunology , vol. 11 , 19 . https://doi.org/10.3389/fimmu.2020.00019

Title: Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD
Author: Hyvärinen, Kati; Koskela, Satu; Niittyvuopio, Riitta; Nihtinen, Anne; Volin, Liisa; Salmenniemi, Urpu; Putkonen, Mervi; Buño, Ismael; Gallardo, David; Itälä-Remes, Maija; Partanen, Jukka; Ritari, Jarmo
Other contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Turku University Hospital




Date: 2020-02-03
Language: eng
Number of pages: 13
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.00019
URI: http://hdl.handle.net/10138/313531
Abstract: Graft-vs.-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation that causes mortality and severe morbidity. Genetic disparities in human leukocyte antigens between the recipient and donor are known contributors to the risk of the disease. However, the overall impact of genetic component is complex, and consistent findings across different populations and studies remain sparse. To gain a comprehensive understanding of the genes responsible for GvHD, we combined genome-wide association studies (GWAS) from two distinct populations with previously published gene expression studies on GvHD in a single gene-level meta-analysis. We hypothesized that genes driving GvHD should be associated in both data modalities and therefore could be detected more readily through their combined effects in the integrated analysis rather than in separate analyses. The meta-analysis yielded a total of 51 acute GvHD-associated genes (false detection rate [FDR]
Subject: 1182 Biochemistry, cell and molecular biology
GvHD
GWAS
gene expression
meta-analysis
HSCT
VERSUS-HOST-DISEASE
MINOR HISTOCOMPATIBILITY ANTIGENS
SINGLE NUCLEOTIDE POLYMORPHISMS
CHRONIC GRAFT
TRANSPLANTATION
RECEPTOR
SUSCEPTIBILITY
METABOLISM
ACTIVATION
PROFILES
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