Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

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Lim , S , Taskinen , M-R & Boren , J 2019 , ' Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome ' , Obesity Reviews , vol. 20 , no. 4 , pp. 599-611 . https://doi.org/10.1111/obr.12820

Title: Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome
Author: Lim, Soo; Taskinen, Marja-Riitta; Boren, Jan
Contributor: University of Helsinki, Clinicum
Date: 2019-04
Language: eng
Number of pages: 13
Belongs to series: Obesity Reviews
ISSN: 1467-7881
URI: http://hdl.handle.net/10138/313692
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue and de novo lipogenesis can lead to NAFLD and insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidaemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is a phenotype of cardiometabolic syndrome. Notably, researchers have discovered a close association between NAFLD and impaired glucose metabolism and focused on the role of NAFLD in the development of type 2 diabetes. Moreover, recent studies provide substantial evidence for an association between NAFLD and atherosclerosis and cardiometabolic disorders. Even if NAFLD can progress into severe liver disorders including nonalcoholic steatohepatitis (NASH) and cirrhosis, the majority of subjects with NAFLD die from cardiovascular disease eventually. In this review, we propose a potential pathological link between NAFLD/NASH and cardiometabolic syndrome. The potential factors that can play a pivotal role in this link, such as inflammation, insulin resistance, alteration in lipid metabolism, oxidative stress, genetic predisposition, and gut microbiota are discussed.
Subject: cardiometabolic syndrome
nonalcoholic fatty liver disease
inflammation
oxidative stress
HEPATIC INSULIN-RESISTANCE
ENDOPLASMIC-RETICULUM STRESS
C-REACTIVE PROTEIN
TERM-FOLLOW-UP
METABOLIC SYNDROME
OXIDATIVE STRESS
GUT MICROBIOTA
CARDIOVASCULAR-DISEASE
ALANINE AMINOTRANSFERASE
RISK-FACTORS
3121 General medicine, internal medicine and other clinical medicine
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