Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification

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http://hdl.handle.net/10138/313985

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Sorsa , T , Alassiri , S , Grigoriadis , A , Räisänen , I T , Pärnänen , P , Nwhator , S O , Gieselmann , D-R & Sakellari , D 2020 , ' Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification ' , Diagnostics , vol. 10 , no. 2 , 61 . https://doi.org/10.3390/diagnostics10020061

Title: Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification
Author: Sorsa, Timo; Alassiri, Saeed; Grigoriadis, Andreas; Räisänen, Ismo T.; Pärnänen, Pirjo; Nwhator, Solomon O.; Gieselmann, Dirk-Rolf; Sakellari, Dimitra
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2020-02
Language: eng
Number of pages: 10
Belongs to series: Diagnostics
ISSN: 2075-4418
URI: http://hdl.handle.net/10138/313985
Abstract: The aim of this study was to investigate the utility of incorporating active matrix metalloproteinase-8 (aMMP-8) as a biomarker into the new periodontitis classification system (stage/grade) presented in 2018. This study included 150 Greek adults aged 25-78, of whom 74 were men and 76 women. Participants were tested with an aMMP-8 point-of-care mouthrinse test, after which a full-mouth clinical examination was performed to assess their periodontal and oral health. The aMMP-8 levels in mouthrinse were significantly lower among healthy patients compared with patients in more severe periodontitis stages and grades (Kruskal-Wallis test and Dunn-Bonferroni test for pairwise post-hoc comparisons; p <0.01 and p <0.05, respectively). Furthermore, aMMP-8 levels were less correlated with plaque levels than bleeding on probing (BOP) (Spearman's rho = 0.269, p <0.001; Spearman's rho = 0.586, p <0.001); respectively). Thus, aMMP-8 was more robust to the confounding effects of oral hygiene than traditional periodontal parameter bleeding on probing. The aMMP-8 point-of-care mouthrinse test can be utilized as an adjunctive and preventive diagnostic tool to identify periodontal disease, classified by stage and grade, and ongoing periodontal breakdown chairside in clinical practice in only 5 min. Overall, integrating aMMP-8 into the new periodontitis classification system seems beneficial.
Subject: periodontitis
diagnosis
matrix metalloproteinase 8
biomarkers
molecular diagnostics
periodontal diseases
point-of-care testing
GINGIVAL CREVICULAR FLUID
MATRIX METALLOPROTEINASE-8
NEUTROPHIL COLLAGENASE
DISEASE
ACTIVATION
MOUTHRINSE
SMOKERS
ENZYME
SALIVA
ADULT
313 Dentistry
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