An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

Show full item record



Permalink

http://hdl.handle.net/10138/314409

Citation

Cosgarea , I , Koelsch , B , Fischer , C , Griewank , K G , van den Berg , L , Kutritz , A , Schadendorf , D & Kindler-Röhrborn , A 2019 , ' An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1) ' , Journal of Investigative Dermatology , vol. 139 , no. 10 , pp. 2235-2238 . https://doi.org/10.1016/j.jid.2019.03.1154

Title: An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)
Author: Cosgarea, Ioana; Koelsch, B.; Fischer, Christine; Griewank, Klaus G.; van den Berg, L.; Kutritz, Anja; Schadendorf, Dirk; Kindler-Röhrborn, Andrea
Contributor: University of Helsinki, External Funding
Date: 2019-10
Language: eng
Number of pages: 6
Belongs to series: Journal of Investigative Dermatology
ISSN: 0022-202X
URI: http://hdl.handle.net/10138/314409
Abstract: Brief Summary Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous keratinization types. Male rats developed significantly more cysts per animal than females. QTL interval mapping yielded three loci on rat chromosomes 1, 8 and 11 (Ccd1, Ccd2, Ccd3) linked to cutaneous cyst formation. Ccd2 proved to be homologous to the human TRICY1 region which could further be narrowed down by genome comparison in both species. It contains 11 genes with evidence of expression in human keratinocytes.
Subject: 3121 General medicine, internal medicine and other clinical medicine
HEREDITARY TRICHILEMMAL CYSTS
EPIDERMAL CYSTS
HEREDITARY TRICHILEMMAL CYSTS
EPIDERMAL CYSTS
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0022202X19314952_main.pdf 6.783Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record