A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction

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http://hdl.handle.net/10138/315725

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Guirado , R , Perez-Rando , M , Ferragud , A , Gutierrez-Castellanos , N , Umemori , J , Carceller , H , Nacher , J & Castillo-Gómez , E 2020 , ' A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction ' , Frontiers in Behavioral Neuroscience , vol. 14 , 51 . https://doi.org/10.3389/fnbeh.2020.00051

Title: A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction
Author: Guirado, Ramon; Perez-Rando, Marta; Ferragud, Antonio; Gutierrez-Castellanos, Nicolas; Umemori, Juzoh; Carceller, Hector; Nacher, Juan; Castillo-Gómez, Esther
Contributor: University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
Date: 2020-04-07
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Behavioral Neuroscience
ISSN: 1662-5153
URI: http://hdl.handle.net/10138/315725
Abstract: The medial prefrontal cortex (mPFC) has been classically defined as the brain region responsible for higher cognitive functions, including the decision-making process. Ample information has been gathered during the last 40 years in an attempt to understand how it works. We now know extensively about the connectivity of this region and its relationship with neuromodulatory ascending projection areas, such as the dorsal raphe nucleus (DRN) or the ventral tegmental area (VTA). Both areas are well-known regulators of the reward-based decision-making process and hence likely to be involved in processes like evidence integration, impulsivity or addiction biology, but also in helping us to predict the valence of our future actions: i.e., what is “good” and what is “bad.” Here we propose a hypothesis of a critical period, during which the inputs of the mPFC compete for target innervation, establishing specific prefrontal network configurations in the adult brain. We discuss how these different prefrontal configurations are linked to brain diseases such as addiction or neuropsychiatric disorders, and especially how drug abuse and other events during early life stages might lead to the formation of more vulnerable prefrontal network configurations. Finally, we show different promising pharmacological approaches that, when combined with the appropriate stimuli, will be able to re-establish these functional prefrontocortical configurations during adulthood.
Subject: 3112 Neurosciences
prefrontal networks
decision-making
critical period
ventral hippocampus
basolateral amygdala
HIPPOCAMPAL VOLUME
VAL66MET POLYMORPHISM
FUNCTIONAL CONNECTIVITY
AMYGDALA CONNECTIVITY
ANTERIOR CINGULATE
SYNAPSE FORMATION
TEMPORAL-ORDER
FRONTAL-CORTEX
MESSENGER-RNA
RAT
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