Causes and Consequences of Hypertriglyceridemia

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http://hdl.handle.net/10138/316278

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Packard , C J , Boren , J & Taskinen , M-R 2020 , ' Causes and Consequences of Hypertriglyceridemia ' , Frontiers in Endocrinology , vol. 11 , 252 . https://doi.org/10.3389/fendo.2020.00252

Title: Causes and Consequences of Hypertriglyceridemia
Author: Packard, Chris J.; Boren, Jan; Taskinen, Marja-Riitta
Contributor: University of Helsinki, HUS Heart and Lung Center
Date: 2020-05-14
Language: eng
Number of pages: 15
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
URI: http://hdl.handle.net/10138/316278
Abstract: Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins-very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circulation of large VLDL-VLDL1-and its lipolytic products, and throughout the VLDL-LDL delipidation cascade perturbations occur that give rise to increased concentrations of remnant lipoproteins and small, dense low-density lipoprotein (LDL). The elevated risk of atherosclerotic cardiovascular disease in hypertriglyceridemia is believed to result from the exposure of the artery wall to these aberrant lipoprotein species. Key regulators of the metabolism of triglyceride-rich lipoproteins have been identified and a number of these are targets for pharmacological intervention. However, a clear picture is yet to emerge as to how to relate triglyceride lowering to reduced risk of atherosclerosis.
Subject: lipid
metabolism
VLDL
chylomicron
apoB
LOW-DENSITY-LIPOPROTEIN
TRIGLYCERIDE-RICH LIPOPROTEINS
APOLIPOPROTEIN-B METABOLISM
ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE
PLASMA TRIGLYCERIDE
C-III
POSTPRANDIAL HYPERTRIGLYCERIDEMIA
APO-B-100 KINETICS
VLDL TRIGLYCERIDE
FATTY-ACIDS
3121 Internal medicine
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