Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts

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Santos , S , Voerman , E , Amiano , P , Barros , H , Beilin , L J , Bergstrom , A , Charles , M-A , Chatzi , L , Chevrier , C , Chrousos , G P , Corpeleijn , E , Costa , O , Costet , N , Crozier , S , Devereux , G , Doyon , M , Eggesbo , M , Fantini , M P , Farchi , S , Forastiere , F , Georgiu , V , Godfrey , K M , Gori , D , Grote , V , Hanke , W , Hertz-Picciotto , I , Heude , B , Hivert , M-F , Hryhorczuk , D , Huang , R-C , Inskip , H , Karvonen , A M , Kenny , L C , Koletzko , B , Kupers , L K , Lagström , H , Lehmann , I , Magnus , P , Majewska , R , Mäkelä , J , Manios , Y , McAuliffe , F M , McDonald , S W , Mehegan , J , Melen , E , Mommers , M , Morgen , C S , Moschonis , G , Murray , D , Ni Chaoimh , C , Nohr , E A , Andersen , A-M N , Oken , E , Oostvogels , A J J M , Pac , A , Papadopoulou , E , Pekkanen , J , Pizzi , C , Polanska , K , Porta , D , Richiardi , L , Rifas-Shiman , S L , Roeleveld , N , Ronfani , L , Santos , A C , Standl , M , Stigum , H , Stoltenberg , C , Thiering , E , Thijs , C , Torrent , M , Tough , S C , Trnovec , T , Turner , S , van Gelder , M M H J , van Rossem , L , von Berg , A , Vrijheid , M , Vrijkotte , T G M , West , J , Wijga , A H , Wright , J , Zvinchuk , O , Sorensen , T I A , Lawlor , D A , Gaillard , R & Jaddoe , V W V 2019 , ' Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts ' , BJOG : An International Journal of Obstetrics & Gynaecology , vol. 126 , no. 8 , pp. 984-995 . https://doi.org/10.1111/1471-0528.15661

Title: Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts
Author: Santos, S.; Voerman, E.; Amiano, P.; Barros, H.; Beilin, L. J.; Bergstrom, A.; Charles, M-A; Chatzi, L.; Chevrier, C.; Chrousos, G. P.; Corpeleijn, E.; Costa, O.; Costet, N.; Crozier, S.; Devereux, G.; Doyon, M.; Eggesbo, M.; Fantini, M. P.; Farchi, S.; Forastiere, F.; Georgiu, V.; Godfrey, K. M.; Gori, D.; Grote, V.; Hanke, W.; Hertz-Picciotto, I.; Heude, B.; Hivert, M-F; Hryhorczuk, D.; Huang, R-C; Inskip, H.; Karvonen, A. M.; Kenny, L. C.; Koletzko, B.; Kupers, L. K.; Lagström, H.; Lehmann, I.; Magnus, P.; Majewska, R.; Mäkelä, J.; Manios, Y.; McAuliffe, F. M.; McDonald, S. W.; Mehegan, J.; Melen, E.; Mommers, M.; Morgen, C. S.; Moschonis, G.; Murray, D.; Ni Chaoimh, C.; Nohr, E. A.; Andersen, A-M Nybo; Oken, E.; Oostvogels, A. J. J. M.; Pac, A.; Papadopoulou, E.; Pekkanen, J.; Pizzi, C.; Polanska, K.; Porta, D.; Richiardi, L.; Rifas-Shiman, S. L.; Roeleveld, N.; Ronfani, L.; Santos, A. C.; Standl, M.; Stigum, H.; Stoltenberg, C.; Thiering, E.; Thijs, C.; Torrent, M.; Tough, S. C.; Trnovec, T.; Turner, S.; van Gelder, M. M. H. J.; van Rossem, L.; von Berg, A.; Vrijheid, M.; Vrijkotte, T. G. M.; West, J.; Wijga, A. H.; Wright, J.; Zvinchuk, O.; Sorensen, T. I. A.; Lawlor, D. A.; Gaillard, R.; Jaddoe, V. W. V.
Contributor: University of Helsinki, Department of Public Health
Date: 2019-07
Language: eng
Number of pages: 12
Belongs to series: BJOG : An International Journal of Obstetrics & Gynaecology
ISSN: 1470-0328
URI: http://hdl.handle.net/10138/317189
Abstract: Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.
Subject: Birthweight
body mass index
pregnancy complications
preterm birth
weight gain
DIABETES-MELLITUS
PRETERM BIRTH
OBESITY
RISK
ASSOCIATION
OUTCOMES
EPIDEMIOLOGY
DISEASE
3123 Gynaecology and paediatrics
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