Adherence to multidomain interventions for dementia prevention : Data from the FINGER and MAPT trials

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HATICE Grp , FINGER Grp , MAPT DSA Grp , Coley , N , Ngandu , T , Lehtisalo , J , Soininen , H , Vellas , B , Richard , E , Kivipelto , M , Andrieu , S , Laatikainen , T & Strandberg , T 2019 , ' Adherence to multidomain interventions for dementia prevention : Data from the FINGER and MAPT trials ' , Alzheimer's & Dementia , vol. 15 , no. 6 , pp. 729-741 . https://doi.org/10.1016/j.jalz.2019.03.005

Title: Adherence to multidomain interventions for dementia prevention : Data from the FINGER and MAPT trials
Author: HATICE Grp; FINGER Grp; MAPT DSA Grp; Coley, Nicola; Ngandu, Tiia; Lehtisalo, Jenni; Soininen, Hilkka; Vellas, Bruno; Richard, Edo; Kivipelto, Miia; Andrieu, Sandrine; Laatikainen, Tiina; Strandberg, Timo
Other contributor: University of Helsinki, Department of Public Health
University of Helsinki, Oral and Maxillofacial Surgery
University of Helsinki, Department of Medicine




Date: 2019-06
Language: eng
Number of pages: 13
Belongs to series: Alzheimer's & Dementia
ISSN: 1552-5260
DOI: https://doi.org/10.1016/j.jalz.2019.03.005
URI: http://hdl.handle.net/10138/318044
Abstract: Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Subject: Prevention
Trial
Adherence
Multidomain
Intervention
FINNISH GERIATRIC INTERVENTION
LIFE-STYLE INTERVENTIONS
PHYSICAL-ACTIVITY
EXERCISE ADHERENCE
ALZHEIMERS-DISEASE
OLDER-ADULTS
COGNITIVE IMPAIRMENT
DISABILITY FINGER
PREDICTORS
DEPRESSION
3112 Neurosciences
3124 Neurology and psychiatry
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