Effects of obesity and a history of gestational diabetes on the risk of postpartum diabetes and hyperglycemia in Chinese Women: Obesity, GDM and diabetes risk

Show full item record



Permalink

http://hdl.handle.net/10138/318721

Citation

Fan , Y , Li , W , Liu , H , Wang , L , Zhang , S , Liu , H , Leng , J , Shen , Y , Tuomilehto , J , Yu , Z , Yang , X , Liu , M & Hu , G 2019 , ' Effects of obesity and a history of gestational diabetes on the risk of postpartum diabetes and hyperglycemia in Chinese Women: Obesity, GDM and diabetes risk ' , Diabetes Research and Clinical Practice , vol. 156 , 107828 . https://doi.org/10.1016/j.diabres.2019.107828

Title: Effects of obesity and a history of gestational diabetes on the risk of postpartum diabetes and hyperglycemia in Chinese Women: Obesity, GDM and diabetes risk
Author: Fan, Yuxin; Li, Weiqin; Liu, Huikun; Wang, Leishen; Zhang, Shuang; Liu, Hongyan; Leng, Junhong; Shen, Yun; Tuomilehto, Jaakko; Yu, Zhijie; Yang, Xilin; Liu, Ming; Hu, Gang
Contributor: University of Helsinki, Clinicum
Date: 2019-10
Language: eng
Number of pages: 9
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
URI: http://hdl.handle.net/10138/318721
Abstract: Objective: To evaluate the independent or combined effects of gestational diabetes (GDM) and pre-pregnancy and postpartum BMI on the odds of postpartum diabetes and hyperglycemia. Methods: The study samples included 1263 women with prior GDM and 705 women without GDM. Postpartum 1-7 years diabetes was diagnosed by the standard oral glucose tolerance test. Results: The multivariable-adjusted odds ratios among women with prior GDM, compared with those without it, were 7.52 for diabetes and 2.27 for hyperglycemia. The multivariable-adjusted odds ratios at different postpartum BMI levels (= 28 kg/m(2)) were 1.00, 2.80, and 8.08 for diabetes (P-trend <0.001), and 1.00, 2.10, and 4.42 for hyperglycemia (P-trend <0.001), respectively. Women with high body fat (>= 31.9%) or abdominal obesity (>= 85 cm) had a 2.7-6.9-fold higher odds ratio for diabetes or hyperglycemia. Women with both obesity and prior GDM had the highest risk of diabetes or hyperglycemia compared with non-obese women without GDM. Non-obese women with prior GDM had the same risk of diabetes and hyperglycemia as non-GDM women with obesity. When using Cox regression models, the results were very close to those using logistic regression models. Conclusions: Maternal prior GDM and pre-pregnancy or postpartum obesity contribute equally to postpartum diabetes and hyperglycemia risk. (C) 2019 Elsevier B.V. All rights reserved.
Subject: 3121 Internal medicine
BMI
gestational diabetes
diabetes risks
METAANALYSIS
FOLLOW-UP
MELLITUS
PREGNANCY
Diabetes risks
WAIST CIRCUMFERENCE
INSULIN-RESISTANCE
GLUCOSE
BODY-MASS INDEX
PHYSICAL-ACTIVITY
Gestational diabetes
ASSOCIATION
3142 Public health care science, environmental and occupational health
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0168822719308198_main.pdf 923.3Kb PDF View/Open
1_s2.0_S0168822719308198_main.pdf 488.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record