Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data

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http://hdl.handle.net/10138/318788

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Kriikku , P , Pelander , A , Rasanen , I & Ojanperä , I 2019 , ' Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data ' , Forensic Science International , vol. 300 , pp. 85-88 . https://doi.org/10.1016/j.forsciint.2019.04.030

Title: Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data
Author: Kriikku, Pirkko; Pelander, Anna; Rasanen, Ilpo; Ojanperä, Ilkka
Contributor: University of Helsinki, Medicum
University of Helsinki, Department of Forensic Medicine
Date: 2019-07
Language: eng
Number of pages: 4
Belongs to series: Forensic Science International
ISSN: 0379-0738
URI: http://hdl.handle.net/10138/318788
Abstract: U-47,700 is a synthetic opioid that emerged on the novel psychoactive substance market a few years ago. After incorporating the substance into the urine UPLC-TOF-MS screening used in post-mortem toxicology, the drug was detected in 10 autopsy cases within routine case work. In all cases, the cause of death was accidental poisoning by U-47,700 alone or in combination with other psychoactive substances. The concentration of U-47,700 in the blood samples ranged between 0.15-2.0 mg/L with a median of 0.30 mg/L. In one of the cases with a U-47,700 concentration of 0.27 mg/L, no other psychoactive substances were detected. The stored TOF-MS analytical data from the year preceding the incorporation of U-47,700 into the screening was reprocessed in order to search for more positive cases. The data-independent acquisition of the original screening allowed for retrospective re-analysis of the full-scan data without additional experiments on the actual sample. The retrospective data-analysis revealed two additional cases positive for U-47,700. The first mention of U-47,700 on a Finnish internet discussion forum was in March 2015. After having been detected in several death cases, the drug was put under national control in November 2016 and the last fatality occurred in 2017. The toxic lifespan of U-47,700 thus lasted for approximately 2 years in Finland. Forensic and clinical laboratories need to rapidly adjust their screening procedures in order to adapt to the continuously expanding field of novel psychoactive substances. Retrospective data-analysis is a practical tool for monitoring the emergence of new substances onto the market. (C) 2019 Elsevier B.V. All rights reserved.
Subject: Time-of-flight mass spectrometry
U-47,700
Novel psychoactive substances
Synthetic opioids
Retrospective data-analysis
LIQUID-CHROMATOGRAPHY
U-47700
FENTANYL
CANNABINOIDS
INTOXICATION
METABOLITES
SAMPLES
DRUGS
HAIR
319 Forensic science and other medical sciences
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