Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam

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Nguyen , T T K , Ngo , T T , Tran , P M , Pham , T T T , Vu , H T T , Nguyen , N T H , Thwaites , G , Virtala , A-M K , Vapalahti , O , Baker , S & Van , T L 2020 , ' Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam ' , Journal of Medical Virology , vol. 92 , no. 8 , pp. 971-981 . https://doi.org/10.1002/jmv.25640

Title: Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam
Author: Nguyen, Tu Thi Kha; Ngo, Tue Tri; Tran, Phuc My; Pham, Tam Thi Thanh; Vu, Hang Thi Ty; Nguyen, Ny Thi Han; Thwaites, Guy; Virtala, Anna-Maija K.; Vapalahti, Olli; Baker, Stephen; Van, Tan Le
Contributor: University of Helsinki, Veterinary Biosciences
University of Helsinki, Helsinki One Health (HOH)
Date: 2020-08
Language: eng
Number of pages: 11
Belongs to series: Journal of Medical Virology
ISSN: 0146-6615
URI: http://hdl.handle.net/10138/318881
Abstract: Active surveillance for zoonotic respiratory viruses is essential to inform the development of appropriate interventions and outbreak responses. Here we target individuals with a high frequency of animal exposure in Vietnam. Three-year community-based surveillance was conducted in Vietnam during 2013-2016. We enrolled a total of 581 individuals (animal-raising farmers, slaughterers, animal-health workers, and rat traders), and utilized reverse transcription-polymerase chain reaction to detect 15 common respiratory viruses in pooled nasal-throat swabs collected at baseline or acute respiratory disease episodes. A respiratory virus was detected in 7.9% (58 of 732) of baseline samples, and 17.7% (136 of 770) of disease episode samples (P <.001), with enteroviruses (EVs), rhinoviruses and influenza A virus being the predominant viruses detected. There were temporal and spatial fluctuations in the frequencies of the detected viruses over the study period, for example, EVs and influenza A viruses were more often detected during rainy seasons. We reported the detection of common respiratory viruses in individuals with a high frequency of animal exposure in Vietnam, an emerging infectious disease hotspot. The results show the value of baseline/control sampling in delineating the causative relationships and have revealed important insights into the ecological aspects of EVs, rhinoviruses and influenza A and their contributions to the burden posed by respiratory infections in Vietnam.
Subject: asymptomatic
cohort study
viral etiology
respiratory disease
Vietnam
zoonoses
INFECTIONS
INFLUENZA
EAST
PATHOGENS
CAMBODIA
LESSONS
11832 Microbiology and virology
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