Early Arterial Intimal Thickening and Plaque Is Related with Treatment Regime and Cardiovascular Disease Risk Factors in Young Adults Following Childhood Hematopoietic Stem Cell Transplantation

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Sundholm , J K M , Suominen , A , Sarkola , T & Jahnukainen , K 2020 , ' Early Arterial Intimal Thickening and Plaque Is Related with Treatment Regime and Cardiovascular Disease Risk Factors in Young Adults Following Childhood Hematopoietic Stem Cell Transplantation ' , Journal of clinical medicine , vol. 9 , no. 7 , 2208 . https://doi.org/10.3390/jcm9072208

Title: Early Arterial Intimal Thickening and Plaque Is Related with Treatment Regime and Cardiovascular Disease Risk Factors in Young Adults Following Childhood Hematopoietic Stem Cell Transplantation
Author: Sundholm, Johnny K. M.; Suominen, Anu; Sarkola, Taisto; Jahnukainen, Kirsi
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
Date: 2020-07
Language: eng
Number of pages: 13
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
URI: http://hdl.handle.net/10138/319235
Abstract: The long-term vascular effects following childhood hematopoietic stem cell transplantation (HSCT) are not well characterized. We compared arterial wall morphology and function using very-high resolution ultrasound (25-55 MHz) in 62 patients following autologous (n= 19) or allogenic (n= 43) HSCT for childhood malignancies and hematological disease (median age 25.9 years, IQR 21.1-30.1; median follow-up time 17.5 years IQR 14.1-23.0) with an age matched healthy control group (n= 44). Intima-media thickness of carotid (CIMT 0.49 +/- 0.11 vs. 0.42 +/- 0.06 mm,p<0.001), brachial, femoral, radial arteries, and local carotid stiffness, but not adventitial thickness, were increased (p<0.001). Diffuse intimal thickening (>0.06 mm) of femoral or radial arteries (n= 17) and subclinical carotid or femoral plaques (n= 18) were more common (p<0.001). Radiation predicted plaques (p<0.001) and local carotid stiffness (p<0.001), but not intimal thickening. CIMT was predicted by age, BMI >30 kg/m(2), hsCRP >2.5 mg/L, hypertension, HbA1c > 42 mmol/L, and cumulative anthracycline >150 mg/m(2). Cumulative metabolic syndrome criteria and cardiovascular disease (CVD) risk factors were more common among HSCT and related with CIMT (p<0.001), but CIMT was similar among controls and HSCT without CVD risk factors. Long-term childhood HSCT survivors show early arterial aging related with radiation, metabolic, and CVD risk factors. Prevention of risk factors could potentially decelerate early arterial wall thickening.
Subject: early vascular ageing
atherosclerosis
radiotherapy
hematopoietic stem cell transplantation
very-high resolution ultrasound
HIGH-RESOLUTION ULTRASOUND
MEDIA THICKNESS
CAROTID ATHEROSCLEROSIS
METABOLIC SYNDROME
CANCER
SURVIVORS
DIAGNOSIS
CHILDREN
3123 Gynaecology and paediatrics
3121 Internal medicine
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