Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood

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http://hdl.handle.net/10138/319692

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Honkamäki , J , Hisinger-Mölkänen , H , Ilmarinen , P , Piirilä , P , Tuomisto , L E , Andersen , H , Huhtala , H , Sovijärvi , A , Backman , H , Lundbäck , B , Rönmark , E , Lehtimäki , L & Kankaanranta , H 2019 , ' Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood ' , Respiratory Medicine , vol. 154 , pp. 56-62 . https://doi.org/10.1016/j.rmed.2019.06.003

Title: Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood
Author: Honkamäki, Jasmin; Hisinger-Mölkänen, Hanna; Ilmarinen, Pinja; Piirilä, Päivi; Tuomisto, Leena E.; Andersen, Heidi; Huhtala, Heini; Sovijärvi, Anssi; Backman, Helena; Lundbäck, Bo; Rönmark, Eva; Lehtimäki, Lauri; Kankaanranta, Hannu
Contributor: University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Medical Imaging Center
Date: 2019
Language: eng
Number of pages: 7
Belongs to series: Respiratory Medicine
ISSN: 0954-6111
URI: http://hdl.handle.net/10138/319692
Abstract: Background: Asthma is currently divided into different phenotypes, with age at onset as a relevant differentiating factor. In addition, asthma with onset in adulthood seems to have a poorer prognosis, but studies investigating age-specific incidence of asthma with a wide age span are scarce. Objective: To evaluate incidence of asthma diagnosis at different ages and differences between child- and adult-diagnosed asthma in a large population-based study, with gender-specific analyzes included. Methods: In 2016, a respiratory questionnaire was sent to 8000 randomly selected subjects aged 20-69 years in western Finland. After two reminders, 4173 (52.3%) subjects responded. Incidence rate of asthma was retrospectively estimated based on the reported age of asthma onset. Adult-diagnosed asthma was defined as a physician-diagnosis of asthma made at >= 18 years of age. Results: Among those with physician-diagnosed asthma, altogether, 63.7% of subjects, 58.4% of men and 67.8% of women, reported adult-diagnosed asthma. Incidence of asthma diagnosis was calculated in 10-year age groups and it peaked in young boys (0-9 years) and middle-aged women (40-49 years) and the average incidence rate during the examined period between 1946 and 2015 was 2.2/1000/year. Adult-diagnosed asthma became the dominant phenotype among those with physician-diagnosed asthma by age of 50 years and 38 years in men and women, respectively. Conclusions: Asthma is mainly diagnosed during adulthood and the incidence of asthma diagnosis peaks in middle-aged women. Asthma diagnosed in adulthood should be considered more in clinical practice and management guidelines.
Subject: Asthma
Incidence
Prevalence
Gender
Adult
Phenotype
OBSTRUCTIVE LUNG-DISEASE
ONSET ASTHMA
RESPIRATORY SYMPTOMS
NORTHERN SWEDEN
REPORTED ASTHMA
NATURAL-HISTORY
PREVALENCE
REMISSION
SMOKING
HEALTH
3121 General medicine, internal medicine and other clinical medicine
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