A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions

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Gabriel , M , Fey , V , Heinosalo , T , Adhikari , P , Rytkönen , K , Komulainen , T , Huhtinen , K , Laajala , T D , Siitari , H , Virkki , A , Suvitie , P , Kujari , H , Aittokallio , T , Perheentupa , A & Poutanen , M 2020 , ' A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions ' , Scientific data , vol. 7 , 284 . https://doi.org/10.1038/s41597-020-00623-x

Title: A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions
Author: Gabriel, Michael; Fey, Vidal; Heinosalo, Taija; Adhikari, Prem; Rytkönen, Kalle; Komulainen, Tuomo; Huhtinen, Kaisa; Laajala, Teemu Daniel; Siitari, Harri; Virkki, Arho; Suvitie, Pia; Kujari, Harry; Aittokallio, Tero; Perheentupa, Antti; Poutanen, Matti
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Helsinki Institute for Information Technology
Date: 2020-08-28
Language: eng
Number of pages: 13
Belongs to series: Scientific data
ISSN: 2052-4463
URI: http://hdl.handle.net/10138/321238
Abstract: Endometriosis is a common inflammatory estrogen-dependent gynecological disorder, associated with pelvic pain and reduced fertility in women. Several aspects of this disorder and its cellular and molecular etiology remain unresolved. We have analyzed the global gene expression patterns in the endometrium, peritoneum and in endometriosis lesions of endometriosis patients and in the endometrium and peritoneum of healthy women. In this report, we present the EndometDB, an interactive web-based user interface for browsing the gene expression database of collected samples without the need for computational skills. The EndometDB incorporates the expression data from 115 patients and 53 controls, with over 24000 genes and clinical features, such as their age, disease stages, hormonal medication, menstrual cycle phase, and the different endometriosis lesion types. Using the web-tool, the end-user can easily generate various plot outputs and projections, including boxplots, and heatmaps and the generated outputs can be downloaded in pdf-format.
Subject: PACKAGE
CELLS
WOMEN
1184 Genetics, developmental biology, physiology
113 Computer and information sciences
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