An epigenome-wide association study of metabolic syndrome and its components

Show full item record



Permalink

http://hdl.handle.net/10138/324364

Citation

Nuotio , M-L , Pervjakova , N , Joensuu , A , Karhunen , V , Hiekkalinna , T , Milani , L , Kettunen , J , Järvelin , M-R , Jousilahti , P , Metspalu , A , Salomaa , V , Kristiansson , K & Perola , M 2020 , ' An epigenome-wide association study of metabolic syndrome and its components ' , Scientific Reports , vol. 10 , no. 1 , 20567 . https://doi.org/10.1038/s41598-020-77506-z

Title: An epigenome-wide association study of metabolic syndrome and its components
Author: Nuotio, Marja-Liisa; Pervjakova, Natalia; Joensuu, Anni; Karhunen, Ville; Hiekkalinna, Tero; Milani, Lili; Kettunen, Johannes; Järvelin, Marjo-Riitta; Jousilahti, Pekka; Metspalu, Andres; Salomaa, Veikko; Kristiansson, Kati; Perola, Markus
Other contributor: University of Helsinki, Quantitative Genetics
University of Helsinki, Quantitative Genetics
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Research Programs Unit






Date: 2020-12-25
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-020-77506-z
URI: http://hdl.handle.net/10138/324364
Abstract: The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its components, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites throughout the genome. Methylation site cg19693031 in gene TXNIP -previously associated with type 2 diabetes, glucose and lipid metabolism, associated with fasting glucose level (P=1.80x10(-8)). Cg06500161 in gene ABCG1 associated both with serum triglycerides (P=5.36x10(-9)) and waist circumference (P=5.21x10(-9)). The previously identified type 2 diabetes-associated locus cg08309687 in chromosome 21 associated with waist circumference for the first time (P=2.24x10(-7)). Furthermore, a novel HDL association with cg17901584 in chromosome 1 was identified (P=7.81x10(-8)). Our study supports previous genetic studies of MetS, finding that lipid metabolism plays a key role in pathology of the syndrome. We provide evidence regarding a close interplay with glucose metabolism. Finally, we suggest that in attempts to identify methylation loci linking separate MetS components, cg19693031 appears to represent a strong candidate.
Subject: DNA METHYLATION
GENETIC-VARIATION
BLOOD
DETERMINANTS
TXNIP
LOCI
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_020_77506_z.pdf 1.280Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record