Ageing and cognition in men with fragile X syndrome

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http://hdl.handle.net/10138/325205

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Sauna-aho , O , BjelogrlicLaakso , N , Rautava , P & Arvio , M 2020 , ' Ageing and cognition in men with fragile X syndrome ' , Journal of Applied Research in Intellectual Disabilities , vol. 33 , no. 5 , pp. 1113-1118 . https://doi.org/10.1111/jar.12733

Title: Ageing and cognition in men with fragile X syndrome
Author: Sauna-aho, Oili; BjelogrlicLaakso, Nina; Rautava, Päivi; Arvio, Maria
Other contributor: University of Helsinki, HYKS erva

Date: 2020-09
Language: eng
Number of pages: 6
Belongs to series: Journal of Applied Research in Intellectual Disabilities
ISSN: 1360-2322
DOI: https://doi.org/10.1111/jar.12733
URI: http://hdl.handle.net/10138/325205
Abstract: Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS. Method A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p <.001). Conclusion Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.
Subject: ageing
cognitive development
fragile X syndrome
intellectual disability
INTELLECTUAL DISABILITIES
LIFE-SPAN
AGE
DEMENTIA
CHILDREN
MALES
TRAJECTORIES
RETARDATION
WEAKNESSES
STRENGTHS
3124 Neurology and psychiatry
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