Adipokine Leptin Co-operates With Mechanosensitive Ca2+-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

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Acheva , A , Kärki , T , Schaible , N , Krishnan , R & Tojkander , S 2021 , ' Adipokine Leptin Co-operates With Mechanosensitive Ca 2+ -Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells ' , Frontiers in Cell and Developmental Biology , vol. 8 , 607038 . https://doi.org/10.3389/fcell.2020.607038

Title: Adipokine Leptin Co-operates With Mechanosensitive Ca2+-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells
Author: Acheva, Anna; Kärki, Tytti; Schaible, Niccole; Krishnan, Ramaswamy; Tojkander, Sari
Contributor: University of Helsinki, Veterinary Biosciences
University of Helsinki, Biosciences
Date: 2021-01-06
Language: eng
Number of pages: 13
Belongs to series: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
URI: http://hdl.handle.net/10138/326360
Abstract: In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that treatment of normal mammary epithelial cells with leptin induces EMT-like features characterized by higher cellular migration speeds, loss of structural ordering of 3D-mammo spheres, and enhancement of epithelial traction forces. Mechanistically, leptin triggers the phosphorylation of myosin light chain kinase-2 (MLC-2) through the interdependent activity of leptin receptor and Ca2+ channels. These data provide evidence that leptin-activated leptin receptors, in co-operation with mechanosensitive Ca2+ channels, play a role in the development of breast carcinomas through the regulation of actomyosin dynamics.
Subject: adipokines
actomyosin
calcium
actin
epithelium
MESENCHYMAL TRANSITION
CANCER CELLS
MYOSIN-II
MOLECULAR-MECHANISMS
CONTRACTILE FORCES
ADIPONECTIN
ADIPOCYTES
EXPRESSION
INVASION
RECEPTOR
1182 Biochemistry, cell and molecular biology
3122 Cancers
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