A Digital-to-Channel Microfluidic Interface via Inkjet Printing of Silver and UV Curing of Thiol-Enes

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http://hdl.handle.net/10138/326664

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Sathyanarayanan, G, Haapala, M, Dixon, C, Wheeler, A R & Sikanen, T M 2020, ' A Digital-to-Channel Microfluidic Interface via Inkjet Printing of Silver and UV Curing of Thiol-Enes ', Advanced Materials Technologies, vol. 5, no. 10, 2000451 . https://doi.org/10.1002/admt.202000451

Title: A Digital-to-Channel Microfluidic Interface via Inkjet Printing of Silver and UV Curing of Thiol-Enes
Author: Sathyanarayanan, Gowtham; Haapala, Markus; Dixon, Christopher; Wheeler, Aaron R.; Sikanen, Tiina M.
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Tiina Sikanen / Chemical Microsystems Lab
Drug Research Program
Date: 2020-10
Language: eng
Number of pages: 9
Belongs to series: Advanced Materials Technologies
ISSN: 2365-709X
DOI: https://doi.org/10.1002/admt.202000451
URI: http://hdl.handle.net/10138/326664
Abstract: Microfluidic sample manipulation is a key enabler in modern chemical biology research. Both discrete droplet-based digital microfluidic (DMF) assays and continuous flow in-channel assays are well established, each featuring unique advantages from the viewpoint of automation and parallelization. However, there are marked differences in the applicable microfabrication materials and methods, which limit the interfacing of DMF sample preparation with in-channel separation systems, such as the gold standard microchip electrophoresis. Simultaneously, there is an increasing demand for low-cost and user-friendly manufacturing techniques to foster the adaptation of microfluidic technology in routine laboratory analyses. This work demonstrates integration of DMF with in-channel separation systems using only low-cost and accessible (non-cleanroom) manufacturing techniques, i.e., inkjet printing of silver for patterning of the driving electrodes and UV curing of off-stoichiometric thiol-ene (OSTE) polymers both for dielectric coating of the electrode arrays and replica molding of the microchannel network. As a dielectric, OSTE performs similar to Parylene C (a gold standard dielectric in electrowetting), whereas its tunable surface and bulk properties facilitate straightforward bonding of the microchannel with the dielectric layer. In addition, a new chip design that facilitates efficient droplet transfer from the DMF part to the microchannel inlet solely by electrowetting is showcased.
Subject: digital microfluidics
inkjet-printed electronics
lab-on-a-chip
off-stoichiometric thiol-enes
replica molding
DEVICE
CHIPS
FILM
116 Chemical sciences
318 Medical biotechnology
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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