Long-term results of surgical resection of lung metastases from soft tissue sarcoma : A single center experience

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http://hdl.handle.net/10138/327001

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Nevala , R , Jäämaa , S , Tukiainen , E , Tarkkanen , M , Räsänen , J , Blomqvist , C & Sampo , M 2019 , ' Long-term results of surgical resection of lung metastases from soft tissue sarcoma : A single center experience ' , Journal of Surgical Oncology , vol. 120 , no. 2 , pp. 168-175 . https://doi.org/10.1002/jso.25504

Title: Long-term results of surgical resection of lung metastases from soft tissue sarcoma : A single center experience
Author: Nevala, Riikka; Jäämaa, Sari; Tukiainen, Erkki; Tarkkanen, Maija; Räsänen, Jari; Blomqvist, Carl; Sampo, Mika
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Marikki Laiho / Principal Investigator
University of Helsinki, HUS Musculoskeletal and Plastic Surgery
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUSLAB
Date: 2019-08
Language: eng
Number of pages: 8
Belongs to series: Journal of Surgical Oncology
ISSN: 0022-4790
URI: http://hdl.handle.net/10138/327001
Abstract: Background A single-institution experience of pulmonary metastasectomy in soft tissue sarcoma (STS) was retrospectively reviewed. Our specific aim was to examine, whether the resection of pulmonary metastases could be curative. We also compared overall survival (OS) of patients after complete or incomplete pulmonary resection and nonsurgical treatment. Methods Between 1987 and 2016, 1580 patients were treated for STS with curative intent by Soft Tissue Sarcoma Group at Helsinki University Hospital, Finland. Three hundred forty-seven patients (22%) developed advanced disease and 130 STS patients (9%) developed pulmonary metastases as first systemic relapse. Seventy four patients (5%) were operated for lung metastases. Results Fifty-five patients (42%) had a complete and 19 (15%) incomplete resection. Fifty-six (43%) were unoperated. Median OS after complete or incomplete metastasectomy, chemotherapy, or best supportive care was 22, 18, 8, and 5 months, respectively. Twelve patients (9%) developed no further metastases and are alive with no evidence of disease. Disease-free survival (DFS) for completely resected patients was 17% at 5 years. All long-term survivors had oligometastatic disease and they underwent one to three complete metastasectomies. Conclusions Complete pulmonary metastasectomy in STS results in 5 years DFS in nearly one-fifth of patients. Most of these patients are probably cured.
Subject: long-term survival
metastasectomy
pulmonary metastases
soft tissue sarcoma
PULMONARY METASTASECTOMY
SURVIVAL
DISEASE
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
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