The effect of amoxicillin on dental enamel development in vivo

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FELTRIN-SOUZA , J , JEREMIAS , F , ALALUUSUA , S , SAHLBERG , C , SANTOS-PINTO , L , JERNVALL , J , SOVA , S , CORDEIRO , R D C L & CERRI , P S 2020 , ' The effect of amoxicillin on dental enamel development in vivo ' , Brazilian Oral Research , vol. 34 , 116 . https://doi.org/10.1590/1807-3107bor-2020.vol34.0116

Title: The effect of amoxicillin on dental enamel development in vivo
Author: FELTRIN-SOUZA, J.; JEREMIAS, F.; ALALUUSUA, S.; SAHLBERG, C.; SANTOS-PINTO, L.; JERNVALL, J.; SOVA, S.; CORDEIRO, R.D.C.L.; CERRI, P.S.
Contributor organization: Clinicum
HUS Head and Neck Center
Department of Oral and Maxillofacial Diseases
Biosciences
Institute of Biotechnology
Date: 2020
Language: eng
Number of pages: 9
Belongs to series: Brazilian Oral Research
ISSN: 1806-8324
DOI: https://doi.org/10.1590/1807-3107bor-2020.vol34.0116
URI: http://hdl.handle.net/10138/327452
Abstract: The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. © 2020
Subject: Amelogenesis
Amoxicillin
Dental Enamel
Dental Enamel Hypoplasia
X-Ray Microtomography
amoxicillin
animal
enamel
enamel hypoplasia
female
incisor
molar tooth
mouse
pregnancy
rat
Animals
Female
Incisor
Mice
Molar
Pregnancy
Rats
313 Dentistry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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