Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity

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dc.contributor.author Lahelma, Mari
dc.contributor.author Luukkonen, Panu K.
dc.contributor.author Qadri, Sami
dc.contributor.author Ahlholm, Noora
dc.contributor.author Lallukka-Brück, Susanna
dc.contributor.author Porthan, Kimmo
dc.contributor.author Juuti, Anne
dc.contributor.author Sammalkorpi, Henna
dc.contributor.author Penttilä, Anne K.
dc.contributor.author Arola, Johanna
dc.contributor.author Orho-Melander, Marju
dc.contributor.author Yki-Järvinen, Hannele
dc.date.accessioned 2021-03-10T14:34:01Z
dc.date.available 2021-03-10T14:34:01Z
dc.date.issued 2021-01
dc.identifier.citation Lahelma , M , Luukkonen , P K , Qadri , S , Ahlholm , N , Lallukka-Brück , S , Porthan , K , Juuti , A , Sammalkorpi , H , Penttilä , A K , Arola , J , Orho-Melander , M & Yki-Järvinen , H 2021 , ' Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity ' , Nutrients , vol. 13 , no. 1 , 169 . https://doi.org/10.3390/nu13010169
dc.identifier.other PURE: 161066005
dc.identifier.other PURE UUID: 69607967-f071-4ec7-af70-224209de1508
dc.identifier.other WOS: 000610655500001
dc.identifier.other ORCID: /0000-0001-9313-9324/work/101179242
dc.identifier.uri http://hdl.handle.net/10138/327751
dc.description.abstract Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 +/- 0.6 kg/m(2)) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA(1c), triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84-0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73-0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Nutrients
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject physical activity
dc.subject diet
dc.subject stress
dc.subject glucose
dc.subject insulin
dc.subject 3143 Nutrition
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity en
dc.type Article
dc.contributor.organization Department of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization Doctoral Programme in Clinical Research
dc.contributor.organization Clinicum
dc.contributor.organization Kardiologian yksikkö
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization II kirurgian klinikka
dc.contributor.organization Department of Surgery
dc.contributor.organization HUSLAB
dc.contributor.organization Department of Pathology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/nu13010169
dc.relation.issn 2072-6643
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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