SARS-CoV-2 infections among healthcare workers at Helsinki University Hospital, Finland, spring 2020 : Serosurvey, symptoms and risk factors

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Kantele , A , Lääveri , T , Kareinen , L , Pakkanen , S H , Blomgren , K , Mero , S , Patjas , A , Virtanen , J , Uusitalo , R , Lappalainen , M , Järvinen , A , Kurkela , S , Jääskeläinen , A J , Vapalahti , O & Sironen , T 2021 , ' SARS-CoV-2 infections among healthcare workers at Helsinki University Hospital, Finland, spring 2020 : Serosurvey, symptoms and risk factors ' , Travel medicine and infectious disease , vol. 39 , 101949 . https://doi.org/10.1016/j.tmaid.2020.101949

Title: SARS-CoV-2 infections among healthcare workers at Helsinki University Hospital, Finland, spring 2020 : Serosurvey, symptoms and risk factors
Author: Kantele, Anu; Lääveri, Tinja; Kareinen, Lauri; Pakkanen, Sari H.; Blomgren, Karin; Mero, Sointu; Patjas, Anu; Virtanen, Jenni; Uusitalo, Ruut; Lappalainen, Maija; Järvinen, Asko; Kurkela, Satu; Jääskeläinen, Anne J.; Vapalahti, Olli; Sironen, Tarja
Contributor organization: Department of Medicine
HUS Inflammation Center
Clinicum
Department of Bacteriology and Immunology
University of Helsinki
HUMI - Human Microbiome Research
Department of Virology
Medicum
HUS Head and Neck Center
Korva-, nenä- ja kurkkutautien klinikka
Department of Diagnostics and Therapeutics
HUSLAB
Research Services
Veterinary Biosciences
Department of Geosciences and Geography
Olli Pekka Vapalahti / Principal Investigator
Viral Zoonosis Research Unit
Staff Services
Helsinki One Health (HOH)
Veterinary Microbiology and Epidemiology
Emerging Infections Research Group
Date: 2021
Language: eng
Number of pages: 7
Belongs to series: Travel medicine and infectious disease
ISSN: 1477-8939
DOI: https://doi.org/10.1016/j.tmaid.2020.101949
URI: http://hdl.handle.net/10138/328346
Abstract: Background: Exposure, risks and immunity of healthcare workers (HCWs), a vital resource during the SARS-CoV-2 pandemic, warrant special attention. Methods: HCWs at Helsinki University Hospital, Finland, filled in questionnaires and provided serum samples for SARS-CoV-2-specific antibody screening by Euroimmun IgG assay in March-April 2020. Positive/equivocal findings were confirmed by Abbott and microneutralization tests. Positivity by two of the three assays or RT-PCR indicated a Covid-19 case (CoV+). Results: The rate of CoV(+) was 3.3% (36/1095) and seropositivity 3.0% (33/1095). CoV(+) was associated with contact with a known Covid-19 case, and working on a Covid-19-dedicated ward or one with cases among staff. The rate in the Covid-19-dedicated ICU was negligible. Smoking and age Conclusion: Undiagnosed and asymptomatic cases among HCWs proved rare. An increased risk was associated with Covid-19-dedicated wards. Particularly high rates were seen for wards with liberal HCW-HCW contacts, highlighting the importance of social distancing also among HCWs.
Subject: Healthcare staff
HCW
SARS-CoV-2
Covid-19
Antibody response
Neutralizing antibodies
3142 Public health care science, environmental and occupational health
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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