Oncolytic Adenoviruses for Cancer Therapy

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Tripodi , L , Vitale , M , Cerullo , V & Pastore , L 2021 , ' Oncolytic Adenoviruses for Cancer Therapy ' , International Journal of Molecular Sciences , vol. 22 , no. 5 , 2517 . https://doi.org/10.3390/ijms22052517

Title: Oncolytic Adenoviruses for Cancer Therapy
Author: Tripodi, Lorella; Vitale, Maria; Cerullo, Vincenzo; Pastore, Lucio
Contributor organization: Drug Research Program
ImmunoViroTherapy Lab
Division of Pharmaceutical Biosciences
Date: 2021-03
Language: eng
Number of pages: 15
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms22052517
URI: http://hdl.handle.net/10138/328950
Abstract: Many immuno-therapeutic strategies are currently being developed to fight cancer. In this scenario, oncolytic adenoviruses (Onc.Ads) have an interesting role for their peculiar tumor selectivity, safety, and transgene-delivery capability. The major strength of the Onc.Ads is the extraordinary immunogenicity that leads to a strong T-cell response, which, together with the possibility of the delivery of a therapeutic transgene, could be more effective than current strategies. In this review, we travel in the adenovirus (Ads) and Onc.Ads world, focusing on a variety of strategies that can enhance Onc.Ads antitumoral efficacy, passing through tumor microenvironment modulation. Onc.Ads-based therapeutic strategies constitute additional weapons in the fight against cancer and appear to potentiate conventional and immune checkpoint inhibitors (ICIs)-based therapies leading to a promising scenario.
Subject: oncolytic adenovirus
cancer
immunovirotherapy
11832 Microbiology and virology
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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