Combined lifestyle factors and the risk of LADA and type 2 diabetes - Results from a Swedish population-based case-control study

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Herzog , K , Ahlqvist , E , Alfredsson , L , Groop , L , Hjort , R , Löfvenborg , J E , Tuomi , T & Carlsson , S 2021 , ' Combined lifestyle factors and the risk of LADA and type 2 diabetes - Results from a Swedish population-based case-control study ' , Diabetes Research and Clinical Practice , vol. 174 , 108760 . https://doi.org/10.1016/j.diabres.2021.108760

Title: Combined lifestyle factors and the risk of LADA and type 2 diabetes - Results from a Swedish population-based case-control study
Author: Herzog, Katharina; Ahlqvist, Emma; Alfredsson, Lars; Groop, Leif; Hjort, Rebecka; Löfvenborg, Josefin E.; Tuomi, Tiinamaija; Carlsson, Sofia
Contributor: University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Centre of Excellence in Complex Disease Genetics
Date: 2021-04
Language: eng
Number of pages: 9
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
URI: http://hdl.handle.net/10138/331810
Abstract: Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34-0.77) and type 2 diabetes (OR 0.09, CI 0.05-0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI < 25 kg/m2 conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43-0.66) and type 2 diabetes (OR 0.12, CI 0.10-0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes. (C) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject: Autoimmune diabetes
LADA
Lifestyle
Type 2 diabetes
ALCOHOL-CONSUMPTION
GENE VARIANTS
ADULTS
SMOKING
ASSOCIATION
VALIDITY
3121 General medicine, internal medicine and other clinical medicine
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