Familial Clustering of Non-alcoholic Fatty Liver Disease

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Title: Familial Clustering of Non-alcoholic Fatty Liver Disease
Author: Huuskonen, Antti
Contributor: University of Helsinki, Faculty of Medicine
Publisher: Helsingin yliopisto
Date: 2021
Language: eng
URI: http://urn.fi/URN:NBN:fi:hulib-202106243232
Thesis level: master's thesis
Degree program: Lääketieteen koulutusohjelma
Degree Programme in Medicine
Utbildningsprogrammet i medicin
Specialisation: Suomenkielinen opintolinja
Study orientation in Finnish
Finskspråkig studieinriktning
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the Western world. It covers a spectrum from simple steatosis to non-alcoholic steatohepatitis (NASH) and cirrhosis. Only a small fraction of patients with NAFLD develop advanced liver disease. We wished to determine whether NAFLD is familial based on review of literature and set up a study to examine index patients and their first degree relatives. The participants underwent a detailed survey of family history and clinical examination. We used transient elastography (TE) as well as magnetic resonance elastography (MRE) to non-invasively measure liver fibrosis. So far we have studied three families in which the index patient had liver cirrhosis due to NAFLD or the index had undergone a liver transplantation due to NAFLD cirrhosis. The review of the literature suggests NAFLD is familial and only 10-30% of its genetic causes have been identified. Our goal is to continue study NAFLD families and to identify new genes underlying NAFLD cirrhosis.
Subject: non-alcoholic fatty liver disease
liver stiffness
familial clustering

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