Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts

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http://hdl.handle.net/10138/332409

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Hyytiäinen , H , Kirjavainen , P V , Täubel , M , Tuoresmäki , P , Casas , L , Heinrich , J , Herberth , G , Standl , M , Renz , H , Piippo-Savolainen , E , Hyvärinen , A , Pekkanen , J & Karvonen , A M 2021 , ' Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts ' , Environmental Research , vol. 196 , 110835 . https://doi.org/10.1016/j.envres.2021.110835

Title: Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts
Author: Hyytiäinen, Heidi; Kirjavainen, Pirkka V.; Täubel, Martin; Tuoresmäki, Pauli; Casas, Lidia; Heinrich, Joachim; Herberth, Gunda; Standl, Marie; Renz, Harald; Piippo-Savolainen, Eija; Hyvärinen, Anne; Pekkanen, Juha; Karvonen, Anne M.
Contributor organization: Department of Public Health
Date: 2021-05
Language: eng
Number of pages: 9
Belongs to series: Environmental Research
ISSN: 0013-9351
DOI: https://doi.org/10.1016/j.envres.2021.110835
URI: http://hdl.handle.net/10138/332409
Abstract: Background Microbial exposures in early childhood direct the development of the immune system and their diversity may influence the risk of allergy development. We aimed to determine whether the indoor microbial diversity at early-life is associated with the development of allergic rhinitis and inhalant atopy. Methods The study population included children within two birth cohorts: Finnish rural-suburban LUKAS (N = 312), and German urban LISA from Munich and Leipzig study centers (N = 248). The indoor microbiota diversity (Chao1 richness and Shannon entropy) was characterized from floor dust samples collected at the child age of 2–3 months by Illumina MiSeq sequencing of bacterial and fungal DNA amplicons. Allergic rhinitis and inhalant atopy were determined at the age of 10 years and analyzed using logistic regression models. Results High bacterial richness (aOR 0.19, 95%CI 0.09–0.42 for middle and aOR 0.12, 95%CI 0.05–0.29 for highest vs. lowest tertile) and Shannon entropy were associated with lower risk of allergic rhinitis in LISA, and similar trend was seen in LUKAS. We observed some significant associations between bacterial and fungal diversity measured and the risk of inhalant atopy, but the associations were inconsistent between the two cohorts. High bacterial diversity tended to be associated with increased risk of inhalant atopy in rural areas, but lower risk in more urban areas. Fungal diversity tended to be associated with increased risk of inhalant atopy only in LISA. Conclusions Our study suggests that a higher bacterial diversity may reduce the risk of allergic rhinitis later in childhood. The environment-dependent heterogeneity in the associations with inhalant atopy – visible here as inconsistent results between two differing cohorts - suggests that specific constituents of the diversity may be relevant.
Subject: Allergic rhinitis
Indoor microbiota
Inhalant atopy
Microbial diversity
EARLY-LIFE
HOUSE-DUST ENDOTOXIN
CHILDHOOD ASTHMA
CHILDREN
SENSITIZATION
DNA
RHINOCONJUNCTIVITIS
RESPIRATORY SYMPTOMS
EXPOSURE
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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