Zebrafish Heart Failure Models

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http://hdl.handle.net/10138/332424

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Narumanchi , S , Wang , H , Perttunen , S , Tikkanen , I , Lakkisto , P & Paavola , J 2021 , ' Zebrafish Heart Failure Models ' , Frontiers in Cell and Developmental Biology , vol. 9 , 662583 . https://doi.org/10.3389/fcell.2021.662583

Title: Zebrafish Heart Failure Models
Author: Narumanchi, Suneeta; Wang, Hong; Perttunen, Sanni; Tikkanen, Ilkka; Lakkisto, Päivi; Paavola, Jere
Contributor organization: Medicum
HUS Abdominal Center
Department of Medicine
Clinicum
Nefrologian yksikkö
University of Helsinki
Helsinki University Hospital Area
HUSLAB
Department of Clinical Chemistry and Hematology
HUS Neurocenter
Date: 2021-05-20
Language: eng
Number of pages: 15
Belongs to series: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
DOI: https://doi.org/10.3389/fcell.2021.662583
URI: http://hdl.handle.net/10138/332424
Abstract: Heart failure causes significant morbidity and mortality worldwide. The understanding of heart failure pathomechanisms and options for treatment remain incomplete. Zebrafish has proven useful for modeling human heart diseases due to similarity of zebrafish and mammalian hearts, fast easily tractable development, and readily available genetic methods. Embryonic cardiac development is rapid and cardiac function is easy to observe and quantify. Reverse genetics, by using morpholinos and CRISPR-Cas9 to modulate gene function, make zebrafish a primary animal model for in vivo studies of candidate genes. Zebrafish are able to effectively regenerate their hearts following injury. However, less attention has been given to using zebrafish models to increase understanding of heart failure and cardiac remodeling, including cardiac hypertrophy and hyperplasia. Here we discuss using zebrafish to study heart failure and cardiac remodeling, and review zebrafish genetic, drug-induced and other heart failure models, discussing the advantages and weaknesses of using zebrafish to model human heart disease. Using zebrafish models will lead to insights on the pathomechanisms of heart failure, with the aim to ultimately provide novel therapies for the prevention and treatment of heart failure.
Subject: 3111 Biomedicine
1182 Biochemistry, cell and molecular biology
zebrafish
heart failure
cardiac remodeling
cardiac hypertrophy
cardiomyopathy
TARGETED GENE DISRUPTION
CARDIAC NEURAL CREST
HYPERTROPHIC CARDIOMYOPATHY
ADULT ZEBRAFISH
VENTRICULAR-FUNCTION
TROPONIN-T
PROTEIN
MUTATIONS
CONTRIBUTES
EXPRESSION
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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