Advances in lipidomics

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http://hdl.handle.net/10138/332472

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Avela , H F & Siren , H 2020 , ' Advances in lipidomics ' , Clinica Chimica Acta , vol. 510 , pp. 123-141 . https://doi.org/10.1016/j.cca.2020.06.049

Title: Advances in lipidomics
Author: Avela, Henri F.; Siren, Heli
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2020-11
Language: eng
Number of pages: 19
Belongs to series: Clinica Chimica Acta
ISSN: 0009-8981
URI: http://hdl.handle.net/10138/332472
Abstract: The present article examines recently published literature on lipids, mainly focusing on research involving glycero-, glycerophospho- and sphingo-lipids. The primary aim is identification of distinct profiles in biologic lipidomic systems by ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS, tandem MS) with multivariate data analysis. This review specifically targets lipid biomarkers and disease pathway mechanisms in humans and artificial targets. Different specimen matrices such as primary blood derivatives (plasma, serum, erythrocytes, and blood platelets), faecal matter, urine, as well as biologic tissues (liver, lung and kidney) are highlighted.
Subject: Lipids
Liquid chromatography
Tandem mass spectrometry
Clinical profiles
Biomarkers
Blood
PERFORMANCE LIQUID-CHROMATOGRAPHY
TANDEM MASS-SPECTROMETRY
FIELD-FLOW FRACTIONATION
PLATELET-ACTIVATING-FACTOR
ESI-QTOF-MS/MS
ELECTROSPRAY-IONIZATION
LC-MS/MS
SAMPLE PREPARATION
STRUCTURAL-CHARACTERIZATION
POTENTIAL BIOMARKERS
116 Chemical sciences
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