Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Show full item record



Permalink

http://hdl.handle.net/10138/332796

Citation

Petersen , A Ø , Julienne , H , Hyötyläinen , T , Sen , P , Fan , Y , Pedersen , H K , Jäntti , S , Hansen , T H , Nielsen , T , Jørgensen , T , Hansen , T , Myers , P N , Nielsen , H B , Ehrlich , S D , Orešič , M & Pedersen , O 2021 , ' Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species ' , Scientific Reports , vol. 11 , no. 1 , 13252 . https://doi.org/10.1038/s41598-021-91482-y

Title: Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species
Author: Petersen, Anders Ø.; Julienne, Hanna; Hyötyläinen, Tuulia; Sen, Partho; Fan, Yong; Pedersen, Helle Krogh; Jäntti, Sirkku; Hansen, Tue H.; Nielsen, Trine; Jørgensen, Torben; Hansen, Torben; Myers, Pernille Neve; Nielsen, H. Bjørn; Ehrlich, S. Dusko; Orešič, Matej; Pedersen, Oluf
Other contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology

Date: 2021-06-24
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-91482-y
URI: http://hdl.handle.net/10138/332796
Abstract: Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.
Subject: MICROBIOME
RECEPTOR
SAMPLES
IMPACT
BLOOD
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_021_91482_y.pdf 2.729Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record