Agreement of Corneal Endothelial Cell Analysis Between Konan-Noncon Robo SP-6000 and Tomey EM-3000 Specular Microscopes in Healthy Subjects

Show full item record



Permalink

http://hdl.handle.net/10138/332975

Citation

Jbara , D , Achiron , A , Antman , G , Buhbut , O , Hecht , I , Tuuminen , R , Bahar , I & Elbaz , U 2021 , ' Agreement of Corneal Endothelial Cell Analysis Between Konan-Noncon Robo SP-6000 and Tomey EM-3000 Specular Microscopes in Healthy Subjects ' , Eye and Contact Lens , vol. 47 , no. 4 , pp. 191-195 . https://doi.org/10.1097/ICL.0000000000000712

Title: Agreement of Corneal Endothelial Cell Analysis Between Konan-Noncon Robo SP-6000 and Tomey EM-3000 Specular Microscopes in Healthy Subjects
Author: Jbara, Doha; Achiron, Asaf; Antman, Gal; Buhbut, Ortal; Hecht, Idan; Tuuminen, Raimo; Bahar, Irit; Elbaz, Uri
Contributor: University of Helsinki, Clinicum
Date: 2021-04
Language: eng
Number of pages: 5
Belongs to series: Eye and Contact Lens
ISSN: 1542-2321
URI: http://hdl.handle.net/10138/332975
Abstract: Purpose: To compare corneal endothelium parameters taken by two common noncontact specular microscopes in healthy subjects. Methods: Healthy participants visiting the outpatient eye clinic at the Rabin Medical Center, Petah Tikva, Israel, were recruited prospectively. All participants underwent three consecutive corneal endothelial cell photographs with both the Konan-Noncon Robo SP-6000 and the Tomey EM-3000 specular microscopes. Endothelial cell density (ECD) was evaluated using the manual center technique in both machines. Bland-Altman graphs were used to assess the agreement between the devices, and intraclass correlation coefficient (ICC) served to assess intraobserver variability for each device. Results: Recruited were 49 healthy subjects with a mean age of 48.9 +/- 15.6 years, 49 right eyes were included. The mean ECD was comparable between the Tomey EM-3000 and the Konan-Noncon Robo SP-6000 (2,713.2 +/- 242.4 vs. 2,700.8 +/- 300.5 cells/mm(2), respectively, P=0.47) with a mean difference of 12.4 cells/mm(2) (0.67%), a mean ECD absolute difference of 93.3 cells/mm(2), and low 95% limits of agreement of -222.0 to +246.9 cells/mm(2). A folded empirical distribution function curve showed that all differences fell within 525.4 cells/mm(2), centered around a median of 13.3 cells/mm(2). Intraclass correlation coefficient was high for both the Konan-Noncon Robo SP-6000 (0.93, 95% confidence interval [CI]: 0.89-0.95) and the Tomey EM-3000 (0.88, 95% CI: 0.82-0.93). Conclusions: The difference in endothelial cell measurements between the Konan SP-6000 and the Tomey EM-3000 specular microscopes through the center and the L-count analyzing techniques, respectively, is clinically small and not statistically significant. Nevertheless, caution should be taken when used interchangeably because ECD difference between the two machines can be as high as 525.4 cells/mm(2).
Subject: Specular microscopy
Endothelial cell count
Tomey EM-3000
Konan-Noncon Robo SP-6000
DENSITY
EYES
3125 Otorhinolaryngology, ophthalmology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
00140068_202104000_00007.pdf 213.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record