A comparative analysis of parechovirus protein structures with other picornaviruses

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Domanska , A , Guryanov , S & Butcher , S J 2021 , ' A comparative analysis of parechovirus protein structures with other picornaviruses ' , Open biology , vol. 11 , no. 7 , 210008 . https://doi.org/10.1098/rsob.210008

Title: A comparative analysis of parechovirus protein structures with other picornaviruses
Author: Domanska, Ausra; Guryanov, Sergey; Butcher, Sarah J.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2021-07-28
Language: eng
Number of pages: 14
Belongs to series: Open biology
ISSN: 2046-2441
URI: http://hdl.handle.net/10138/333238
Abstract: Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornavirus) infections. In this parechovirus review, we focus on the cleaved protein products resulting from the polyprotein processing after translation comparing and contrasting their known or predicted structures and functions to those of other picornaviruses. The review also includes our original analysis from sequence and structure prediction. This review highlights significant structural differences between parechoviral and other picornaviral proteins, suggesting that parechovirus drug development should specifically be directed to parechoviral targets.
Subject: picornavirus
parechovirus
structure
RNA stem-loop
function
POLIOVIRUS POLYPEPTIDE 3CD
DEPENDENT RNA-POLYMERASE
COMMON COLD VIRUS
CRYSTAL-STRUCTURE
MEMBRANE PERMEABILIZATION
GENOMIC CHARACTERIZATION
ENTEROVIRUS REPLICATION
NUCLEOTIDE-SEQUENCE
ATP HYDROLYSIS
LJUNGAN VIRUS
1182 Biochemistry, cell and molecular biology
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