3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography

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Tuohinen , S S , Skyttä , T , Huhtala , H , Poutanen , T , Virtanen , V , Kellokumpu-Lehtinen , P-L & Raatikainen , P 2021 , ' 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography ' , JACC: Cardiooncology , vol. 3 , no. 2 , pp. 277-289 . https://doi.org/10.1016/j.jaccao.2021.03.005

Title: 3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography
Author: Tuohinen, Suvi Sirkku; Skyttä, Tanja; Huhtala, Heini; Poutanen, Tuija; Virtanen, Vesa; Kellokumpu-Lehtinen, Pirkko-Liisa; Raatikainen, Pekka
Contributor: University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Kardiologian yksikkö
Date: 2021-06
Language: eng
Number of pages: 13
Belongs to series: JACC: Cardiooncology
ISSN: 2666-0873
URI: http://hdl.handle.net/10138/333420
Abstract: BACKGROUND Radiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function. OBJECTIVES The aim of this study was to explore RT-associated changes in left ventricular (LV) diastolic function. METHODS Sixty chemotherapy-naive patients with left-sided, early-stage breast cancer were studied with speckle tracking echocardiography at 3 time points: prior to, immediately after, and 3 years after RT. Global and regional early diastolic strain rate (SRe) were quantified, as were parameters of systolic function. RESULTS Regional changes in SRe, particularly the apical and anteroseptat segments, were observed over time and were more evident than global changes. The apical SRe declined from a median of 1.24 (interquartile range: 1.01 to 1.39) s(-1) at baseline to 1.02 (interquartile range: 0.79 to 1.15) s(-1) at 3 years of follow-up (p < 0.001). This decline was associated with the left ventricular maximal radiation dose (beta = 0.36, p = 0.007). The global SRe was CONCLUSIONS RT resulted in changes in the SRe in the apical and anteroseptat segments over 3 years of follow-up. Changes in SRe apical segments were present even in patients with preserved systolic function and were independently associated with RT dose and cardiovascular comorbidities. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Subject: breast cancer
diastolic strain rate
radiotherapy
speckle tracking echocardiography
BREAST-CANCER PATIENTS
GLOBAL STRAIN-RATE
RADIOTHERAPY
DYSFUNCTION
MECHANISMS
TOXICITY
DISEASE
DAMAGE
RISK
3122 Cancers
3121 General medicine, internal medicine and other clinical medicine
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