Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity

Show full item record



Permalink

http://hdl.handle.net/10138/333484

Citation

Grotell , M , den Hollander , B , Jalkanen , A , Törrönen , E , Ihalainen , J , de Miguel , E , Dudek , M , Kettunen , M I , Hyytiä , P , Forsberg , M M , Kankuri , E & Korpi , E R 2021 , ' Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity ' , Frontiers in Pharmacology , vol. 12 , 679759 . https://doi.org/10.3389/fphar.2021.679759

Title: Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity
Author: Grotell, Milo; den Hollander, Bjornar; Jalkanen, Aaro; Törrönen, Essi; Ihalainen, Jouni; de Miguel, Elena; Dudek, Mateusz; Kettunen, Mikko I.; Hyytiä, Petri; Forsberg, Markus M.; Kankuri, Esko; Korpi, Esa R.
Contributor: University of Helsinki, Medicum
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Pharmacology
University of Helsinki, Helsinki In Vivo Animal Imaging Platform (HAIP)
University of Helsinki, Esko Markus Kankuri / Principal Investigator
University of Helsinki, Department of Pharmacology
Date: 2021-04-28
Language: eng
Number of pages: 13
Belongs to series: Frontiers in Pharmacology
ISSN: 1663-9812
URI: http://hdl.handle.net/10138/333484
Abstract: Mephedrone (4-MMC), despite its illegal status, is still a widely used psychoactive substance. Its effects closely mimic those of the classical stimulant drug methamphetamine (METH). Recent research suggests that unlike METH, 4-MMC is not neurotoxic on its own. However, the neurotoxic effects of 4-MMC may be precipitated under certain circumstances, such as administration at high ambient temperatures. Common use of 4-MMC in conjunction with alcohol raises the question whether this co-consumption could also precipitate neurotoxicity. A total of six groups of adolescent rats were treated twice daily for four consecutive days with vehicle, METH (5 mg/kg) or 4-MMC (30 mg/kg), with or without ethanol (1.5 g/kg). To investigate persistent delayed effects of the administrations at two weeks after the final treatments, manganese-enhanced magnetic resonance imaging brain scans were performed. Following the scans, brains were collected for Golgi staining and spine analysis. 4-MMC alone had only subtle effects on neuronal activity. When administered with ethanol, it produced a widespread pattern of deactivation, similar to what was seen with METH-treated rats. These effects were most profound in brain regions which are known to have high dopamine and serotonin activities including hippocampus, nucleus accumbens and caudate-putamen. In the regions showing the strongest activation changes, no morphological changes were observed in spine analysis. By itself 4-MMC showed few long-term effects. However, when co-administered with ethanol, the apparent functional adaptations were profound and comparable to those of neurotoxic METH.
Subject: stimulant
ethanol
co-consumption
MEMRI
golgi-staining
methamphetamine
mephedrone
NUCLEUS-ACCUMBENS
NERVE-ENDINGS
METHAMPHETAMINE
AMPHETAMINE
BRAIN
NEUROTOXICITY
INCREASES
DOPAMINE
ETHANOL
STRESS
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
fphar_12_679759.pdf 1.669Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record