Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

Show full item record



Permalink

http://hdl.handle.net/10138/333691

Citation

Aalto-Setälä, L.; Uppstu, P.; Sinitsyna, P.; Lindfors, N.C.; Hupa, L. Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions. Materials 2021, 14, 4834.

Title: Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions
Author: Aalto-Setälä, Laura; Uppstu, Peter; Sinitsyna, Polina; Lindfors, Nina C.; Hupa, Leena
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2021-08-26
URI: http://hdl.handle.net/10138/333691
Abstract: The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.


Files in this item

Total number of downloads: Loading...

Files Size Format View
materials-14-04834.pdf 3.072Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record