A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy : Efficacy and Humoral Immune Responses in 50 Children

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Palosuo , K , Karisola , P , Savinko , T , Fyhrquist , N , Alenius , H & Mäkelä , M J 2021 , ' A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy : Efficacy and Humoral Immune Responses in 50 Children ' , Journal of allergy and clinical immunology: In practice , vol. 9 , no. 5 , pp. 1892-+ . https://doi.org/10.1016/j.jaip.2021.01.020

Title: A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy : Efficacy and Humoral Immune Responses in 50 Children
Author: Palosuo, Kati; Karisola, Piia; Savinko, Terhi; Fyhrquist, Nanna; Alenius, Harri; Mäkelä, Mika J.
Contributor: University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, HUMI - Human Microbiome Research
University of Helsinki, Institute of Biotechnology
University of Helsinki, Karolinska Institutet
University of Helsinki, HUMI - Human Microbiome Research
University of Helsinki, HUS Inflammation Center
Date: 2021-05
Language: eng
Number of pages: 11
Belongs to series: Journal of allergy and clinical immunology: In practice
ISSN: 2213-2198
URI: http://hdl.handle.net/10138/334454
Abstract: BACKGROUND: Egg allergy is the second most common food allergy in children. Persistent food allergy increases the risk of anaphylaxis and reduces the quality of life. OBJECTIVE: To determine the efficacy of oral immunotherapy (OIT) with raw egg white powder and study its effects on humoral responses in children with persistent egg allergy. METHODS: Fifty children aged 6 to 17 years with egg allergy, diagnosed by double-blind, placebo-controlled food challenge, were randomized 3:2 to 8 months of OIT with a maintenance dose of 1 g of egg white protein or 6 months of avoidance after which the avoidance group crossed over to OIT. We examined changes in IgE, IgG4, and IgA concentrations to Gal d 1-4 during OIT compared with avoidance and assessed clinical reactivity at 8 and 18 months. RESULTS: After 8 months, 22 of 50 children (44%) on OIT and 1 of 21 (4.8%) on egg avoidance were desensitized to the target dose, 23 of 50 (46%) were partially desensitized (dose
Subject: Desensitization
Egg allergens
Gal d 1
Hen's egg allergy
Oral immunotherapy
Ovalbumin
Ovomucoid
Tolerance
DOUBLE-BLIND
SUSTAINED UNRESPONSIVENESS
ALLERGEN IMMUNOTHERAPY
NATURAL-HISTORY
FOOD ALLERGY
IGE
3121 General medicine, internal medicine and other clinical medicine
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