Structural white matter connectometry of reading and dyslexia

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Sihvonen , A J , Virtala , P , Thiede , A , Laasonen , M & Kujala , T 2021 , ' Structural white matter connectometry of reading and dyslexia ' , NeuroImage , vol. 241 , 118411 . https://doi.org/10.1016/j.neuroimage.2021.118411

Title: Structural white matter connectometry of reading and dyslexia
Author: Sihvonen, Aleksi J.; Virtala, Paula; Thiede, Anja; Laasonen, Marja; Kujala, Teija
Other contributor: University of Helsinki, Cognitive Brain Research Unit
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Medicum
University of Helsinki, Behavioural Sciences
University of Helsinki, Mind and Matter








Date: 2021-11-01
Language: eng
Number of pages: 10
Belongs to series: NeuroImage
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2021.118411
URI: http://hdl.handle.net/10138/334550
Abstract: Current views on the neural network subserving reading and its deficits in dyslexia rely largely on evidence derived from functional neuroimaging studies. However, understanding the structural organization of reading and its aberrations in dyslexia requires a hodological approach, studies of which have not provided consistent findings. Here, we adopted a whole brain hodological approach and investigated relationships between structural white matter connectivity and reading skills and phonological processing in a cross-sectional study of 44 adults using individual local connectome matrix from diffusion MRI data. Moreover, we performed quantitative anisotropy aided differential tractography to uncover structural white matter anomalies in dyslexia (23 dyslexics and 21 matched controls) and their correlation to reading-related skills. The connectometry analyses indicated that reading skills and phonological processing were both associated with corpus callosum (tapetum), forceps major and minor, as well as cerebellum bilaterally. Furthermore, the left dorsal and right thalamic pathways were associated with phonological processing. Differential tractography analyses revealed structural white matter anomalies in dyslexics in the left ventral route and bilaterally in the dorsal route compared to the controls. Connectivity deficits were also observed in the corpus callosum, forceps major, vertical occipital fasciculus and corticostriatal and thalamic pathways. Altered structural connectivity in the observed differential tractography results correlated with poor reading skills and phonological processing. Using a hodological approach, the current study provides novel evidence for the extent of the reading-related connectome and its aberrations in dyslexia. The results conform current functional neuroanatomical models of reading and developmental dyslexia but provide novel network-level and tract-level evidence on structural connectivity anomalies in dyslexia, including the vertical occipital fasciculus.
Subject: BRAIN CONNECTIVITY
DEVELOPMENTAL DYSLEXIA
DIFFUSION
DTI
Dyslexia
FIBER PATHWAYS
INDIVIDUAL-DIFFERENCES
METAANALYSIS
MICROSTRUCTURE
NEURAL SYSTEMS
Phonological processing
Reading
SPATIAL STATISTICS
Structural connectometry
TRACTOGRAPHY
6162 Cognitive science
515 Psychology
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