Personalised Advanced Therapies in Parkinson's Disease : The Role of Non-Motor Symptoms Profile

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http://hdl.handle.net/10138/335359

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Leta , V , Dafsari , H S , Sauerbier , A , Metta , V , Titova , N , Timmermann , L , Ashkan , K , Samuel , M , Pekkonen , E , Odin , P , Antonini , A , Martinez-Martin , P , Parry , M , van Wamelen , D J & Ray Chaudhuri , K 2021 , ' Personalised Advanced Therapies in Parkinson's Disease : The Role of Non-Motor Symptoms Profile ' , Journal of personalized medicine , vol. 11 , no. 8 , 773 . https://doi.org/10.3390/jpm11080773

Title: Personalised Advanced Therapies in Parkinson's Disease : The Role of Non-Motor Symptoms Profile
Author: Leta, Valentina; Dafsari, Haidar S.; Sauerbier, Anna; Metta, Vinod; Titova, Nataliya; Timmermann, Lars; Ashkan, Keyoumars; Samuel, Michael; Pekkonen, Eero; Odin, Per; Antonini, Angelo; Martinez-Martin, Pablo; Parry, Miriam; van Wamelen, Daniel J.; Ray Chaudhuri, K.
Contributor organization: HUS Neurocenter
Neurologian yksikkö
Date: 2021-08
Language: eng
Number of pages: 11
Belongs to series: Journal of personalized medicine
ISSN: 2075-4426
DOI: https://doi.org/10.3390/jpm11080773
URI: http://hdl.handle.net/10138/335359
Abstract: Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson's disease (PD). Currently, selection of device-aided therapies is mainly focused on patients' motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.
Subject: Parkinson's disease
device-aided therapies
non-motor symptoms
personalised medicine
apomorphine
levodopa-carbidopa intestinal gel
deep brain stimulation
DEEP-BRAIN-STIMULATION
CARBIDOPA INTESTINAL GEL
INTRAJEJUNAL LEVODOPA INFUSION
SUBCUTANEOUS APOMORPHINE
MOTOR
NEUROSTIMULATION
COMPLICATIONS
MULTICENTER
IMPACT
FORCE
3141 Health care science
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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