A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration

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Ahmadian , Z , Rebelo Correia , A M , Hasany , M , Figueiredo , P , Dobakhti , F , Reza Eskandari , M , Hosseini , S , Abiri , R , Khorshid , S , Hirvonen , J , Santos , H A & Shahbazi , M-A 2021 , ' A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration ' , Advanced Healthcare Materials , vol. 10 , no. 3 , 2001122 . https://doi.org/10.1002/adhm.202001122

Title: A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration
Author: Ahmadian, Zainab; Rebelo Correia, Alexandra Maria; Hasany, Masoud; Figueiredo, Patricia; Dobakhti, Faramarz; Reza Eskandari, Mohammad; Hosseini, Seyed; Abiri, Ramin; Khorshid, Shiva; Hirvonen, Jouni; Santos, Hélder A.; Shahbazi, Mohammad-Ali
Other contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Drug Research Program
University of Helsinki, Helsinki One Health (HOH)
University of Helsinki, Nanomedicines and Biomedical Engineering






Date: 2021-02-03
Language: eng
Number of pages: 19
Belongs to series: Advanced Healthcare Materials
ISSN: 2192-2640
DOI: https://doi.org/10.1002/adhm.202001122
URI: http://hdl.handle.net/10138/335657
Abstract: Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges of effective wound repair. Herein, a multifunctional extracellular matrix‐mimicking hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid (TA) as a green chemistry approach. The hydrogel shows adjustable physicochemical properties by altering the concentration of TA and it represents high safety features both in vitro and in vivo on fibroblasts, red blood cells, and mice organs. In addition to the merit of facile encapsulation of cell proliferation‐inducing hydrophilic drugs, accelerated healing of skin injury is obtained through pH‐dependent release of TA and its multifaceted mechanisms as an antibacterial, antioxidant, hemostatic, and anti‐inflammatory moiety. The developed gelatin‐TA (GelTA) hydrogel also shows an outstanding effect on the formation of extracellular matrix and wound closure in vivo via offered cell adhesion sites in the backbone of gelatin that provide increased re‐epithelialization and better collagen deposition. These results suggest that the multifunctional GelTA hydrogel is a promising candidate for the clinical treatment of full‐thickness wounds and further development of wound dressing materials that releases active agents in the neutral or slightly basic environment of infected nonhealing wounds.
Subject: ADHESIVENESS
ALLANTOIN
ANTIBACTERIAL
ANTIOXIDANT
DELIVERY
EXTENSIBILITY
FABRICATION
GELATIN
INJECTABLE HYDROGEL
NANOPARTICLES
allantoin
anti&#8208
bacterial hyrdogels
hemorrhage
hydrogels and gelatin
tannic acid
wound dressing
1182 Biochemistry, cell and molecular biology
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