Intestinal SALSA/dmbt1 levels are decreased in prematurely born infants

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http://hdl.handle.net/10138/336047

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Reichhardt , M P , Messing , M , Andersson , S , Kolho , K-L & Meri , S 2021 , ' Intestinal SALSA/dmbt1 levels are decreased in prematurely born infants ' , Scandinavian Journal of Immunology , vol. 93 , no. 2 , 12987 . https://doi.org/10.1111/sji.12987

Title: Intestinal SALSA/dmbt1 levels are decreased in prematurely born infants
Author: Reichhardt, Martin Parnov; Messing, Marcel; Andersson, Sture; Kolho, Kaija-Leena; Meri, Seppo
Contributor organization: Department of Bacteriology and Immunology
TRIMM - Translational Immunology Research Program
Research Programs Unit
University of Helsinki
Medicum
Seppo Meri / Principal Investigator
Clinicum
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
HUSLAB
Date: 2021-02
Language: eng
Number of pages: 8
Belongs to series: Scandinavian Journal of Immunology
ISSN: 0300-9475
DOI: https://doi.org/10.1111/sji.12987
URI: http://hdl.handle.net/10138/336047
Abstract: The first months of life represent a crucial time period for an infant. Alongside establishing the early microbiome, the mucosal immunological homeostasis is being developed. Both processes may be perturbed in prematurely born infants. The glycoprotein SALSA plays a role in mucosal inflammation and microbial clearance. It is one of the most abundant molecules on the intestinal mucosal surfaces in early life. SALSA binds to many types of microbes and host defence molecules like IgA, C1q and collectin molecules. We here describe the development in faecal SALSA levels during the first three months of life. During these 90 days, the median SALSA level in full-term babies decreased from 1100 mu g/mL (range 49-17 000 mu g/mL) to 450 mu g/mL (range 33-1000 mu g/mL). Lower levels of SALSA were observed in prematurely born infants in the same time period. Our novel observation thus indicates an impact of prematurity on an important component of the infant intestinal immune system. Changes in SALSA in early life may have an effect on the early establishment of the human microbiome.
Subject: C1q
complement
dmbt1
gp340
IgA
infant
intestine
premature
SALIVARY SCAVENGER
BACTERIAL RECOGNITION
DMBT1
RECEPTOR
GLYCOPROTEIN-340
MOLECULE
GP-340
LUNG
DIFFERENTIATION
SUPERFAMILY
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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