CMC is more than a measure of corticospinal tract integrity in acute stroke patients

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http://hdl.handle.net/10138/336698

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Aikio , R , Laaksonen , K , Sairanen , A , Parkkonen , E , Abou Elseoud , A , Kujala , J & Forss , N 2021 , ' CMC is more than a measure of corticospinal tract integrity in acute stroke patients ' , NeuroImage: Clinical , vol. 32 , 102818 . https://doi.org/10.1016/j.nicl.2021.102818

Title: CMC is more than a measure of corticospinal tract integrity in acute stroke patients
Author: Aikio, R.; Laaksonen, K.; Sairanen, A; Parkkonen, E.; Abou Elseoud, A.; Kujala, J.; Forss, N.
Other contributor: University of Helsinki, Department of Neurosciences
University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Neurologian yksikkö







Date: 2021
Language: eng
Number of pages: 8
Belongs to series: NeuroImage: Clinical
ISSN: 2213-1582
DOI: https://doi.org/10.1016/j.nicl.2021.102818
URI: http://hdl.handle.net/10138/336698
Abstract: In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magneto encephalographic oscillatory signals were recorded from 29 patients with paresis of the upper extremity due to ischemic stroke and 22 control subjects. CMC amplitudes and peak frequencies at 13-30 Hz were compared between the two groups. In the patients, the peak frequency in both the affected and the unaffected hemisphere was significantly (p < 0.01) lower and the strength of CMC was significantly (p < 0.05) weaker in the affected hemisphere compared to the control subjects. The strength of CMC in the patients correlated with the level of tactile sensitivity and clinical test results of hand function. In contrast, no correlation between measures of CST integrity and CMC was found. The results confirm the earlier findings that CMC is altered in acute stroke and demonstrate that CMC is bidirectional and not solely a measure of integrity of the efferent corticospinal tract.
Subject: Afferent input
Corticomuscular coherence
Corticospinal tract integrity
Magnetoencephalography
Motor cortex
Stroke
MOTOR-CORTICAL OSCILLATIONS
CORTICOMUSCULAR COHERENCE
CORTEX EXCITABILITY
DIFFUSION TENSOR
EEG-EMG
MUSCLE
SYNCHRONIZATION
CONTRACTION
REORGANIZATION
PRECISION
3112 Neurosciences
3124 Neurology and psychiatry
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