A widespread viral entry mechanism : The C-end Rule motif-neuropilin receptor interaction

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Balistreri , G , Yamauchi , Y & Teesalu , T 2021 , ' A widespread viral entry mechanism : The C-end Rule motif-neuropilin receptor interaction ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 118 , no. 49 , 2112457118 . https://doi.org/10.1073/pnas.2112457118

Title: A widespread viral entry mechanism : The C-end Rule motif-neuropilin receptor interaction
Author: Balistreri, Giuseppe; Yamauchi, Yohei; Teesalu, Tambet
Contributor organization: Department of Virology
Helsinki Institute of Sustainability Science (HELSUS)
Date: 2021-12-07
Language: eng
Number of pages: 6
Belongs to series: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
DOI: https://doi.org/10.1073/pnas.2112457118
URI: http://hdl.handle.net/10138/338091
Abstract: Many phylogenetically distant animal viruses, including the new coronavirus severe acute respiratory syndrome coronavirus 2, have surface proteins with polybasic sites that are cleaved by host furin and furin-like proteases. Other than priming certain viral surface proteins for fusion, cleavage generates a carboxy-terminal RXXR sequence. This C-end Rule (CendR) motif is known to bind to neuropilin (NRP) receptors on the cell surface. NRPs are ubiquitously expressed, pleiotropic cell surface receptors with important roles in growth factor signaling, vascular biology, and neurobiology, as well as immune homeostasis and activation. The CendR-NRP receptor interaction promotes endocytic internalization and tissue spreading of different cargo, including viral particles. We propose that the interaction between viral surface proteins and NRPs plays an underappreciated and prevalent role in the transmission and pathogenesis of diverse viruses and represents a promising broad-spectrum antiviral target.
Subject: neuropilin
C-end Rule
virus
internalization
GROWTH FACTOR-A
INFLUENZA-VIRUS
PROTEOLYTIC ACTIVATION
CUTTING EDGE
CELL
TRAFFICKING
HEMAGGLUTININ
ACQUISITION
VIRULENCE
CLEAVAGE
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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