L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms : Nausea, Headache, Stress and Anxiety

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Eriksson , C J P , Metsälä , M , Möykkynen , T , Mäkisalo , H , Kärkkäinen , O , Palmen , M , Salminen , J E & Kauhanen , J 2020 , ' L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms : Nausea, Headache, Stress and Anxiety ' , Alcohol & Alcoholism , vol. 55 , no. 6 , pp. 660-666 . https://doi.org/10.1093/alcalc/agaa082

Title: L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms : Nausea, Headache, Stress and Anxiety
Author: Eriksson, C. J. Peter; Metsälä, Markus; Möykkynen, Tommi; Mäkisalo, Heikki; Kärkkäinen, Olli; Palmen, Maria; Salminen, Joonas E.; Kauhanen, Jussi
Contributor organization: Clinicum
Department of Public Health
Department of Chemistry
University of Helsinki
Receptor Biochemistry
Molecular and Integrative Biosciences Research Programme
Biosciences
HUS Abdominal Center
IV kirurgian klinikka
Oral and Maxillofacial Surgery
Date: 2020-11
Language: eng
Number of pages: 7
Belongs to series: Alcohol & Alcoholism
ISSN: 0735-0414
DOI: https://doi.org/10.1093/alcalc/agaa082
URI: http://hdl.handle.net/10138/339340
Abstract: Aims: Alcohol-related hangover symptoms: nausea, headache, stress and anxiety cause globally considerable amount of health problems and economic losses. Many of these harmful effects are produced by alcohol and its metabolite, acetaldehyde, which also is a common ingredient in alcohol beverages. The aim of the present study is to investigate the effect of the amino acid L-cysteine on the alcohol/acetaldehyde related aftereffects. Methods: Voluntary healthy participants were recruited through advertisements. Volunteers had to have experience of hangover and/or headache. The hangover study was randomized, double-blind and placebo-controlled. Nineteen males randomly swallowed placebo and L-cysteine tablets. The alcohol dose was 1.5 g/kg, which was consumed during 3 h. Results: The primary results based on correlational analysis showed that L-cysteine prevents or alleviates hangover, nausea, headache, stress and anxiety. For hangover, nausea and headache the results were apparent with the L-cysteine dose of 1200 mg and for stress and anxiety already with the dose of 600 mg. Conclusions: L-cysteine would reduce the need of drinking the next day with no or less hangover symptoms: nausea, headache, stress and anxiety. Altogether, these effects of L-cysteine are unique and seem to have a future in preventing or alleviating these harmful symptoms as well as reducing the risk of alcohol addiction.
Description: Correction ALCOHOL AND ALCOHOLISM Volume: 55 Issue: 6 Pages: 705-705 DOI: 10.1093/alcalc/agaa088 Published: NOV 2020
Subject: TOBACCO-SMOKE
ACETALDEHYDE
EXTRACT
ETHANOL
SCALE
3142 Public health care science, environmental and occupational health
3112 Neurosciences
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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